scholarly journals In silico Design, Synthesis and Pharmacological screening of Quinazolinones as NMDA receptor antagonists for Anticonvulsant activity: Part II

2015 ◽  
Vol 7 (4) ◽  
pp. 303-310 ◽  
Author(s):  
Amit G Nerkar ◽  
Megha Sahu ◽  
Shweta Valvi ◽  
Sanjay D Sawant
Keyword(s):  
Nmda Receptor ◽  
In Silico ◽  
Anticonvulsant Activity ◽  
Nmda Receptor Antagonists ◽  
Receptor Antagonists ◽  
Design Synthesis ◽  
In Silico Design ◽  
Pharmacological Screening

Structural investigations by in silico modeling for designing NR2B subunit selective NMDA receptor antagonists

RSC Advances ◽  
2015 ◽  
Vol 5 (30) ◽  
pp. 23922-23940 ◽  
Author(s):  
Vishal P. Zambre ◽  
Varsha A. Hambarde ◽  
Nilesh N. Petkar ◽  
Chinmay N. Patel ◽  
Sanjay D. Sawant
Keyword(s):  
Nmda Receptor ◽  
In Silico ◽  
Nmda Receptor Antagonists ◽  
Nr2b Subunit ◽  
Receptor Antagonists ◽  
Structural Requirements ◽  
Structural Investigations ◽  
In Silico Modeling

In this paper, structural requirements for optimization of NR2B subunit selective NMDA receptor antagonists are discussed.

Design, Synthesis, and Pharmacological Characterization of Novel, Potent NMDA Receptor Antagonists

2004 ◽  
Vol 47 (27) ◽  
pp. 6740-6748 ◽  
Author(s):  
Paola Conti ◽  
Marco De Amici ◽  
Giovanni Grazioso ◽  
Gabriella Roda ◽  
Federico F. Barberis Negra ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Nmda Receptor Antagonists ◽  
Receptor Antagonists ◽  
Pharmacological Characterization ◽  
Design Synthesis

Design, Synthesis, Pharmacological Evaluation and Docking Studies of GluN2B-Selective NMDA Receptor Antagonists with a Benzo[7]annulen-7-amine Scaffold

ChemMedChem ◽  
2017 ◽  
Vol 12 (15) ◽  
pp. 1212-1222 ◽  
Author(s):  
Sandeep Gawaskar ◽  
Louisa Temme ◽  
Julian A. Schreiber ◽  
Dirk Schepmann ◽  
Alessandro Bonifazi ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Docking Studies ◽  
Nmda Receptor Antagonists ◽  
Receptor Antagonists ◽  
Design Synthesis ◽  
Pharmacological Evaluation

Design, Synthesis, and Biological Evaluation of 3-Benzazepin-1-ols as NR2B-Selective NMDA Receptor Antagonists

ChemMedChem ◽  
2010 ◽  
Vol 5 (5) ◽  
pp. 687-695 ◽  
Author(s):  
Bastian Tewes ◽  
Bastian Frehland ◽  
Dirk Schepmann ◽  
Kai-Uwe Schmidtke ◽  
Thomas Winckler ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Biological Evaluation ◽  
Nmda Receptor Antagonists ◽  
Receptor Antagonists ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation
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