Hippocampal sparing whole brain irradiation: Experience in our department

2016 ◽  
Vol 32 ◽  
pp. 224
Author(s):  
P. Dorado Rodríguez ◽  
D. Planes Meseguer ◽  
R.D. Esposito ◽  
L. Fernández Fornos ◽  
S. Miranda Labajos
Keyword(s):  
Whole Brain Irradiation ◽  
Whole Brain ◽  
Brain Irradiation ◽  
Hippocampal Sparing

PO-1513: Overdose areas in whole brain irradiation with simultaneous integrated boost and hippocampal sparing

2020 ◽  
Vol 152 ◽  
pp. S817
Author(s):  
A. Pierelli ◽  
M.G. Giri ◽  
P.M. Polloniato ◽  
N.L.V. Cernusco ◽  
R. Micera ◽  
...  
Keyword(s):  
Simultaneous Integrated Boost ◽  
Whole Brain Irradiation ◽  
Whole Brain ◽  
Brain Irradiation ◽  
Integrated Boost ◽  
Hippocampal Sparing

scholarly journals EP-1347: Hypofractionated whole brain irradiation with hippocampal sparing and SIB for metastases: a dosimetric VMAT study

2015 ◽  
Vol 115 ◽  
pp. S726
Author(s):  
G. Sicignano ◽  
N. Giaj Levra ◽  
A. Fiorentino ◽  
S. Fersino ◽  
F. Ricchetti ◽  
...  
Keyword(s):  
Whole Brain Irradiation ◽  
Whole Brain ◽  
Brain Irradiation ◽  
Hippocampal Sparing

scholarly journals Phase II trial of hippocampal-sparing whole brain irradiation with simultaneous integrated boost for metastatic cancer

2020 ◽  
Vol 22 (12) ◽  
pp. 1831-1839 ◽  
Author(s):  
Kenneth D Westover ◽  
J Travis Mendel ◽  
Tu Dan ◽  
Kiran Kumar ◽  
Ang Gao ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Brain Metastasis ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Simultaneous Integrated Boost ◽  
Whole Brain Irradiation ◽  
Whole Brain ◽  
Brain Irradiation ◽  
Integrated Boost ◽  
Hippocampal Sparing

Abstract Background Advanced radiotherapeutic treatment techniques limit the cognitive morbidity associated with whole-brain radiotherapy (WBRT) for brain metastasis through avoidance of hippocampal structures. However, achieving durable intracranial control remains challenging. Methods We conducted a single-institution single-arm phase II trial of hippocampal-sparing whole brain irradiation with simultaneous integrated boost (HSIB-WBRT) to metastatic deposits in adult patients with brain metastasis. Radiation therapy consisted of intensity-modulated radiation therapy delivering 20 Gy in 10 fractions over 2–2.5 weeks to the whole brain with a simultaneous integrated boost of 40 Gy in 10 fractions to metastatic lesions. Hippocampal regions were limited to 16 Gy. Cognitive performance and cancer outcomes were evaluated. Results A total of 50 patients, median age 60 years (interquartile range, 54–65), were enrolled. Median progression-free survival was 2.9 months (95% CI: 1.5–4.0) and overall survival was 9 months. As expected, poor survival and end-of-life considerations resulted in a high exclusion rate from cognitive testing. Nevertheless, mean decline in Hopkins Verbal Learning Test–Revised delayed recall (HVLT-R DR) at 3 months after HSIB-WBRT was only 10.6% (95% CI: −36.5‒15.3%). Cumulative incidence of local and intracranial failure with death as a competing risk was 8.8% (95% CI: 2.7‒19.6%) and 21.3% (95% CI: 10.7‒34.2%) at 1 year, respectively. Three grade 3 toxicities consisting of nausea, vomiting, and necrosis or headache were observed in 3 patients. Scores on the Multidimensional Fatigue Inventory 20 remained stable for evaluable patients at 3 months. Conclusions HVLT-R DR after HSIB-WBRT was significantly improved compared with historical outcomes in patients treated with traditional WBRT, while achieving intracranial control similar to patients treated with WBRT plus stereotactic radiosurgery (SRS). This technique can be considered in select patients with multiple brain metastases who cannot otherwise receive SRS.

Whole brain irradiation with hippocampal sparing and dose escalation on multiple brain metastases

2015 ◽  
Vol 191 (6) ◽  
pp. 461-469 ◽  
Author(s):  
Oliver Oehlke ◽  
David Wucherpfennig ◽  
Franziska Fels ◽  
Lars Frings ◽  
Karl Egger ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Dose Escalation ◽  
Whole Brain Irradiation ◽  
Whole Brain ◽  
Brain Irradiation ◽  
Multiple Brain Metastases ◽  
Hippocampal Sparing

OC-0561 WHOLE BRAIN IRRADIATION WITH HIPPOCAMPAL SPARING AND DOSE ESCALATION ON MULTIPLE BRAIN METASTASES

2012 ◽  
Vol 103 ◽  
pp. S224-S225
Author(s):  
F. Fels ◽  
N. Wiedenmann ◽  
M. Schmucker ◽  
C. Nieder ◽  
A.L. Grosu ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Dose Escalation ◽  
Whole Brain Irradiation ◽  
Whole Brain ◽  
Brain Irradiation ◽  
Multiple Brain Metastases ◽  
Hippocampal Sparing
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