Elimination of the free sulfhydryl group in the human serum albumin (HSA) moiety of human interferon-α2b and HSA fusion protein increases its stability against mechanical and thermal stresses

2009 ◽  
Vol 72 (2) ◽  
pp. 405-411 ◽  
Author(s):  
Hong Liang Zhao ◽  
Chong Xue ◽  
Yang Wang ◽  
Bo Sun ◽  
Xue Qin Yao ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Fusion Protein ◽  
Serum Albumin ◽  
Human Serum ◽  
Thermal Stresses ◽  
Sulfhydryl Group ◽  
Human Interferon ◽  
Free Sulfhydryl Group ◽  
Interferon Α2b

Disruption ofPichia pastoris PMR1 gene decreases its folding capacity on human serum albumin and interferon-α2b fusion protein

Yeast ◽  
2008 ◽  
Vol 25 (4) ◽  
pp. 279-286 ◽  
Author(s):  
Hong Liang Zhao ◽  
Chong Xue ◽  
Yang Wang ◽  
Qing Fen Duan ◽  
Xiang Hua Xiong ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Fusion Protein ◽  
Serum Albumin ◽  
Human Serum ◽  
Interferon Α2b

Circumventing the heterogeneity and instability of human serum albumin-interferon-α2b fusion protein by altering its orientation

2007 ◽  
Vol 131 (3) ◽  
pp. 245-252 ◽  
Author(s):  
Hong Liang Zhao ◽  
Chong Xue ◽  
Yang Wang ◽  
Xian Yu Li ◽  
Xiang Hua Xiong ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Fusion Protein ◽  
Serum Albumin ◽  
Human Serum ◽  
Interferon Α2b

Reaction of Nitric Oxide with the Free Sulfhydryl Group of Human Serum Albumin Yields a Sulfenic Acid and Nitrous Oxide

Biochemistry ◽  
1995 ◽  
Vol 34 (36) ◽  
pp. 11494-11499 ◽  
Author(s):  
Eugene G. DeMaster ◽  
Barry J. Quast ◽  
Beth Redfern ◽  
Herbert T. Nagasawa
Keyword(s):  
Nitric Oxide ◽  
Nitrous Oxide ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Sulfhydryl Group ◽  
Sulfenic Acid ◽  
Free Sulfhydryl Group

Increasing the homogeneity, stability and activity of human serum albumin and interferon-α2b fusion protein by linker engineering

2008 ◽  
Vol 61 (1) ◽  
pp. 73-77 ◽  
Author(s):  
Hong Liang Zhao ◽  
Xue Qin Yao ◽  
Chong Xue ◽  
Yang Wang ◽  
Xiang Hua Xiong ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Fusion Protein ◽  
Serum Albumin ◽  
Human Serum ◽  
Interferon Α2b

Long-Acting Human Serum Albumin-Thioredoxin Fusion Protein Suppresses Bleomycin-Induced Pulmonary Fibrosis Progression

2013 ◽  
Vol 345 (2) ◽  
pp. 271-283 ◽  
Author(s):  
Ryota Tanaka ◽  
Hiroshi Watanabe ◽  
Azusa Kodama ◽  
Victor Tuan Giam Chuang ◽  
Yu Ishima ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Pulmonary Fibrosis ◽  
Fusion Protein ◽  
Serum Albumin ◽  
Human Serum ◽  
Fibrosis Progression ◽  
Long Acting

Bioengineered Human Serum Albumin Fusion Protein as Target/Enzyme/pH Three-Stage Propulsive Drug Vehicle for Tumor Therapy

ACS Nano ◽  
2020 ◽  
Vol 14 (12) ◽  
pp. 17405-17418
Author(s):  
Mingyu Wang ◽  
Li Zhang ◽  
Yanfei Cai ◽  
Yang Yang ◽  
Lipeng Qiu ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Fusion Protein ◽  
Serum Albumin ◽  
Human Serum ◽  
Tumor Therapy ◽  
Drug Vehicle ◽  
Target Enzyme

scholarly journals TIMP-2 Fusion Protein with Human Serum Albumin Potentiates Anti-Angiogenesis-Mediated Inhibition of Tumor Growth by Suppressing MMP-2 Expression

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e35710 ◽  
Author(s):  
Mi-Sook Lee ◽  
Jae-In Jung ◽  
Seung-Hae Kwon ◽  
Sang-Mok Lee ◽  
Kyoji Morita ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Fusion Protein ◽  
Tumor Growth ◽  
Serum Albumin ◽  
Human Serum ◽  
Inhibition Of Tumor Growth
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