Prostate-Specific Antigen (PSA) Isoform p2PSA Significantly Improves the Prediction of Prostate Cancer at Initial Extended Prostate Biopsies in Patients with Total PSA Between 2.0 and 10 ng/ml: Results of a Prospective Study in a Clinical Setting

2011 ◽  
Vol 60 (2) ◽  
pp. 214-222 ◽  
Author(s):  
Giorgio Guazzoni ◽  
Luciano Nava ◽  
Massimo Lazzeri ◽  
Vincenzo Scattoni ◽  
Giovanni Lughezzani ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prospective Study ◽  
Prostate Specific Antigen ◽  
Clinical Setting ◽  
Specific Antigen ◽  
Prostate Biopsies ◽  
Total Psa ◽  
A Prospective Study

On the Clinical Usefulness of the Free-to-Total Prostate-Specific Antigen Ratio

2006 ◽  
Vol 21 (1) ◽  
pp. 1-5 ◽  
Author(s):  
S. Ciatto ◽  
T. Rubeca ◽  
R. Franceschini ◽  
C. Trevisiol ◽  
M. Confortini ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Clinical Usefulness ◽  
Clinical Use ◽  
Prostate Biopsies ◽  
Total Prostate Specific Antigen ◽  
Total Psa

The free-to-total prostate-specific antigen ratio (F/T PSA) is associated with the presence of prostate cancer and is thus used as an indicator for suspicion of prostate cancer and as a determinant for biopsy. We reviewed a recent retrospective series of 966 consecutive prostate biopsies where F/T PSA was blindly determined and did not influence biopsy indication. We simulated the association of F/T PSA with biopsy outcome and its impact as a biopsy determinant. When adopting an F/T PSA cutoff of 10%, 13%, 16% or 20% among random sextant biopsies in the 4–10 ng/mL total PSA range, the sensitivity was 15%, 37%, 55% and 72% and the specificity 89%, 80%, 64% and 44%, respectively. Using F/T PSA as a biopsy determinant, from 1.7 to 2.6 cancer biopsies would have been delayed to avoid 10 benign biopsies. As this balance is not acceptable, F/T PSA has no role as a biopsy indicator and its clinical use is questionable.

scholarly journals Dietary Lycopene, Angiogenesis, and Prostate Cancer: A Prospective Study in the Prostate-Specific Antigen Era

2014 ◽  
Vol 106 (2) ◽  
pp. djt430-djt430 ◽  
Author(s):  
K. Zu ◽  
L. Mucci ◽  
B. A. Rosner ◽  
S. K. Clinton ◽  
M. Loda ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prospective Study ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
A Prospective Study

Diagnostic Performance of PCA3 to Detect Prostate Cancer in Men with Increased Prostate Specific Antigen: A Prospective Study of 1,962 Cases

2012 ◽  
Vol 188 (5) ◽  
pp. 1726-1731 ◽  
Author(s):  
E. David Crawford ◽  
Kyle O. Rove ◽  
Edouard J. Trabulsi ◽  
Junqi Qian ◽  
Krystyna P. Drewnowska ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prospective Study ◽  
Prostate Specific Antigen ◽  
Diagnostic Performance ◽  
Specific Antigen ◽  
Detect Prostate Cancer ◽  
Antigen A ◽  
A Prospective Study

Complexed prostate-specific antigen as a staging tool for prostate cancer: a prospective study in 420 men

Urology ◽  
2002 ◽  
Vol 60 (4) ◽  
pp. 18-23 ◽  
Author(s):  
Lori J Sokoll ◽  
Leslie A Mangold ◽  
Alan W Partin ◽  
Jonathan I Epstein ◽  
Debra J Bruzek ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prospective Study ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
A Prospective Study
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