The role of diurnal fluctuations in excitatory amino acid carrier 1 levels in post-ischemic hippocampal Zn2+ accumulation

2021 ◽  
Vol 336 ◽  
pp. 113538
Author(s):  
Takaaki Aratake ◽  
Youichirou Higashi ◽  
Tomoya Hamada ◽  
Yusuke Ueba ◽  
Takahiro Shimizu ◽  
...  
2020 ◽  
Vol 21 (16) ◽  
pp. 5676
Author(s):  
Minwoo Lee ◽  
Dong Gyun Ko ◽  
Dae Ki Hong ◽  
Man-Sup Lim ◽  
Bo Young Choi ◽  
...  

Although there have been substantial advances in knowledge regarding the mechanisms of neuron death after stroke, effective therapeutic measures for stroke are still insufficient. Excitatory amino acid carrier 1 (EAAC1) is a type of neuronal glutamate transporter and considered to have an additional action involving the neuronal uptake of cysteine, which acts as a crucial substrate for glutathione synthesis. Previously, our lab demonstrated that genetic deletion of EAAC1 leads to decreased neuronal glutathione synthesis, increased oxidative stress, and subsequent cognitive impairment. Therefore, we hypothesized that reduced neuronal transport of cysteine due to deletion of the EAAC1 gene might exacerbate neuronal injury and impair adult neurogenesis in the hippocampus after transient cerebral ischemia. EAAC1 gene deletion profoundly increased ischemia-induced neuronal death by decreasing the antioxidant capacity. In addition, genetic deletion of EAAC1 also decreased the overall neurogenesis processes, such as cell proliferation, differentiation, and survival, after cerebral ischemia. These studies strongly support our hypothesis that EAAC1 is crucial for the survival of newly generated neurons, as well as mature neurons, in both physiological and pathological conditions. Here, we present a comprehensive review of the role of EAAC1 in neuronal death and neurogenesis induced by ischemic stroke, focusing on its potential cellular and molecular mechanisms.


2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Chengbo Yang ◽  
Dale Lackeyram ◽  
Tania Archbold ◽  
Yoshinori Mine ◽  
Ming Fan

Sign in / Sign up

Export Citation Format

Share Document