N-methyl-D-aspartate receptors, L-type voltage-operated calcium channels and neuronal nitric oxide synthase forms a calcium/redox nano-switch within lipid rafts in cerebellar granule neurons in culture

2012 ◽  
Vol 53 ◽  
pp. S177-S178
Author(s):  
D. Marques-da-Silva⁎ ◽  
C. Gutierrez-Merino
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Calcium Channels ◽  
Lipid Rafts ◽  
Neuronal Nitric Oxide Synthase ◽  
Cerebellar Granule Neurons ◽  
Granule Neurons ◽  
Cerebellar Granule ◽  
Oxide Synthase ◽  
Voltage Operated Calcium Channels

Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons

2014 ◽  
Vol 459 (2) ◽  
pp. 251-263 ◽  
Author(s):  
Shingo Kasamatsu ◽  
Yasuo Watanabe ◽  
Tomohiro Sawa ◽  
Takaaki Akaike ◽  
Hideshi Ihara
Keyword(s):  
Nitric Oxide ◽  
Neuronal Nitric Oxide Synthase ◽  
Cerebellar Granule Neurons ◽  
Ros Generation ◽  
Granule Neurons ◽  
Cerebellar Granule ◽  
Haem Oxygenase ◽  
Oxide Synthase ◽  
Signal Regulation ◽  
Generation Activity

Phosphorylation of neuronal nitric oxide synthase at Ser847 increased its ROS generation activity and changed the ratio of NO to ROS to regulate intracellular redox signalling, which is involved in neuroprotection against apoptosis via HO-1 (haem oxygenase 1) expression in cerebellar granule neurons.

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