scholarly journals Stimulation of the cAMP pathway protects cultured cerebellar granule neurons against alcohol-induced cell death by activating the neuronal nitric oxide synthase (nNOS) gene

2007 ◽  
Vol 1143 ◽  
pp. 34-45 ◽  
Author(s):  
Bahri Karaçay ◽  
Guiying Li ◽  
Nicholas J. Pantazis ◽  
Daniel J. Bonthius
Keyword(s):  
Nitric Oxide ◽  
Cell Death ◽  
Nitric Oxide Synthase ◽  
Neuronal Nitric Oxide Synthase ◽  
Cerebellar Granule Neurons ◽  
Granule Neurons ◽  
Cerebellar Granule ◽  
Camp Pathway ◽  
Oxide Synthase ◽  
Stimulation Of

Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons

2014 ◽  
Vol 459 (2) ◽  
pp. 251-263 ◽  
Author(s):  
Shingo Kasamatsu ◽  
Yasuo Watanabe ◽  
Tomohiro Sawa ◽  
Takaaki Akaike ◽  
Hideshi Ihara
Keyword(s):  
Nitric Oxide ◽  
Neuronal Nitric Oxide Synthase ◽  
Cerebellar Granule Neurons ◽  
Ros Generation ◽  
Granule Neurons ◽  
Cerebellar Granule ◽  
Haem Oxygenase ◽  
Oxide Synthase ◽  
Signal Regulation ◽  
Generation Activity

Phosphorylation of neuronal nitric oxide synthase at Ser847 increased its ROS generation activity and changed the ratio of NO to ROS to regulate intracellular redox signalling, which is involved in neuroprotection against apoptosis via HO-1 (haem oxygenase 1) expression in cerebellar granule neurons.

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