ROS-Mediated UV-Induced Inside-Out Signaling in HaCaT Human Keratinocytes and SKH-1 Mouse Skin

2013 ◽  
Vol 65 ◽  
pp. S20-S21
Author(s):  
Aaron Holley ◽  
Ines Batinic-Haberle ◽  
Daret St. Clair
Keyword(s):  
Mouse Skin ◽  
Human Keratinocytes ◽  
Inside Out

scholarly journals Manganese Superoxide Dismutase-Mediated Inside-Out Signaling in HaCaT Human Keratinocytes and SKH-1 Mouse Skin

2014 ◽  
Vol 20 (15) ◽  
pp. 2347-2360 ◽  
Author(s):  
Aaron K. Holley ◽  
Yong Xu ◽  
Teresa Noel ◽  
Vasudevan Bakthavatchalu ◽  
Ines Batinic-Haberle ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Manganese Superoxide Dismutase ◽  
Mouse Skin ◽  
Human Keratinocytes ◽  
Manganese Superoxide ◽  
Inside Out

Ultraviolet (UV) B radiation causes an upregulation of Survivin in human keratinocytes and mouse skin

2004 ◽  
Author(s):  
Moammir Hasan Aziz ◽  
Amaninderpal S. Ghotra ◽  
Yogeshwer Shukla ◽  
Nihal Ahmad
Keyword(s):  
Mouse Skin ◽  
Human Keratinocytes

scholarly journals An Engrailed1 enhancer underlies human thermoregulatory evolution

2020 ◽  
Author(s):  
Daniel Aldea ◽  
Yuji Atsuta ◽  
Blerina Kokalari ◽  
Stephen Schaffner ◽  
Bailey Warder ◽  
...  
Keyword(s):  
Genetic Basis ◽  
Mouse Skin ◽  
Human Keratinocytes ◽  
Eccrine Sweat Gland ◽  
Recurrent Mutation ◽  
Eccrine Gland ◽  
Enhancer Activity ◽  
Eccrine Glands ◽  
Human Ortholog ◽  
Altered Regulation

SummaryHumans rely on sweating to cool off and have the highest eccrine sweat gland density among mammals. We investigated whether altered regulation of the Engrailed 1 (EN1) gene, the levels of which are critical for patterning eccrine glands during development, could underlie the evolution of this defining human trait. First, we identify five EN1 candidate enhancers (ECEs) using comparative genomics and validation of enhancer activity in mouse skin. The human ortholog of one ECE, hECE18, contains multiple derived substitutions that together dramatically increase the activity of this enhancer in keratinocytes. Targeted repression of hECE18 reduces EN1 expression in human keratinocytes, indicating hECE18 upregulates EN1 in this context. Finally, we find that hECE18 increases ectodermal En1 in a humanized knock-in mouse to increase eccrine gland number. Our study uncovers a genetic basis for the evolution of one of the most singular human adaptations and implicates the recurrent mutation of a single enhancer as a novel mechanism for evolutionary change.

Ultraviolet-B Radiation Causes an Upregulation of Survivin in Human Keratinocytes and Mouse Skin¶

2004 ◽  
Vol 80 (3) ◽  
pp. 602 ◽  
Author(s):  
Moammir Hasan Aziz ◽  
Amaninderapal S. Ghotra ◽  
Yogeshwer Shukla ◽  
Nihal Ahmad
Keyword(s):  
Mouse Skin ◽  
Human Keratinocytes ◽  
Ultraviolet B ◽  
Ultraviolet B Radiation

Ultraviolet-B Radiation Causes an Upregulation of Survivin in Human Keratinocytes and Mouse Skin¶

2007 ◽  
Vol 80 (3) ◽  
pp. 602-608 ◽  
Author(s):  
Moammir Hasan Aziz ◽  
Amaninderapal S. Ghotra ◽  
Yogeshwer Shukla ◽  
Nihal Ahmad
Keyword(s):  
Mouse Skin ◽  
Human Keratinocytes ◽  
Ultraviolet B ◽  
Ultraviolet B Radiation

scholarly journals Ligation of the β4 Integrin Triggers Adhesion Behavior of Human Keratinocytes by an “Inside-out” Mechanism

2004 ◽  
Vol 123 (3) ◽  
pp. 444-451 ◽  
Author(s):  
Stefan Kippenberger ◽  
Stefan Loitsch ◽  
Jutta Müller ◽  
Maike Guschel ◽  
Roland Kaufmann ◽  
...  
Keyword(s):  
Human Keratinocytes ◽  
Adhesion Behavior ◽  
Β4 Integrin ◽  
Inside Out
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