The stochastic nature of genome organization and function

2022 ◽  
Vol 72 ◽  
pp. 45-52
Author(s):  
Varun Sood ◽  
Tom Misteli
Keyword(s):  
Genome Organization ◽  
Stochastic Nature ◽  
And Function

scholarly journals Chromosome genomics uncovers plant genome organization and function

2021 ◽  
Vol 46 ◽  
pp. 107659
Author(s):  
Jana Zwyrtková ◽  
Hana Šimková ◽  
Jaroslav Doležel
Keyword(s):  
Genome Organization ◽  
Plant Genome ◽  
And Function

scholarly journals Technologies to study spatial genome organization: beyond 3C

2019 ◽  
Author(s):  
Nadine Übelmesser ◽  
Argyris Papantonis
Keyword(s):  
Genome Organization ◽  
Nuclear Organization ◽  
Three Dimensional ◽  
Nuclear Space ◽  
Chromosome Conformation ◽  
Novel Variants ◽  
Cell Processes ◽  
Systematic Biases ◽  
And Function ◽  
Spatial Genome Organization

Abstract The way that chromatin is organized in three-dimensional nuclear space is now acknowledged as a factor critical for the major cell processes, like transcription, replication and cell division. Researchers have been armed with new molecular and imaging technologies to study this structure-to-function link of genomes, spearheaded by the introduction of the ‘chromosome conformation capture’ technology more than a decade ago. However, this technology is not without shortcomings, and novel variants and orthogonal approaches are being developed to overcome these. As a result, the field of nuclear organization is constantly fueled by methods of increasing resolution and/or throughput that strive to eliminate systematic biases and increase precision. In this review, we attempt to highlight the most recent advances in technology that promise to provide novel insights on how chromosomes fold and function.

scholarly journals Genome organization at different scales: nature, formation and function

2018 ◽  
Vol 52 ◽  
pp. 145-153 ◽  
Author(s):  
Jacques Serizay ◽  
Julie Ahringer
Keyword(s):  
Genome Organization ◽  
And Function

scholarly journals Comprehensive, human cellular protein databases and their implication for the study of genome organization and function

FEBS Letters ◽  
1989 ◽  
Vol 244 (2) ◽  
pp. 247-254 ◽  
Author(s):  
Julio E. Celis ◽  
Gitte P. Ratz ◽  
Peder Madsen ◽  
Borbala Gesser ◽  
Jette B. Lauridsen ◽  
...  
Keyword(s):  
Genome Organization ◽  
Cellular Protein ◽  
Protein Databases ◽  
And Function

scholarly journals The BEAF-32 insulator coordinates genome organization and function during the evolution of Drosophila species

2012 ◽  
Vol 22 (11) ◽  
pp. 2199-2207 ◽  
Author(s):  
J. Yang ◽  
E. Ramos ◽  
V. G. Corces
Keyword(s):  
Genome Organization ◽  
Drosophila Species ◽  
And Function

Polydnavirus-wasp associations: evolution, genome organization, and function

2013 ◽  
Vol 3 (5) ◽  
pp. 587-594 ◽  
Author(s):  
Michael R Strand ◽  
Gaelen R Burke
Keyword(s):  
Genome Organization ◽  
And Function

scholarly journals Three-Dimensional Genome Organization and Function in Drosophila

Genetics ◽  
2017 ◽  
Vol 205 (1) ◽  
pp. 5-24 ◽  
Author(s):  
Yuri B. Schwartz ◽  
Giacomo Cavalli
Keyword(s):  
Genome Organization ◽  
Three Dimensional ◽  
And Function

scholarly journals DNA co-methylation networks outline the structure and remodeling dynamics of colorectal cancer epigenome

2018 ◽  
Author(s):  
Izaskun Mallona ◽  
Susanna Aussó ◽  
Anna Díez-Villanueva ◽  
Víctor Moreno ◽  
Miguel A. Peinado
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Colon Cancer ◽  
Genome Organization ◽  
Tumor Tissue ◽  
Network Modeling ◽  
Genome Architecture ◽  
Epigenetic Mark ◽  
And Function ◽  
Unique Signature

AbstractEpigenomic plasticity is interconnected with chromatin structure and gene regulation. In tumor progression, orchestrated remodeling of genome organization accompanies the acquisition of malignant properties. DNA methylation, a key epigenetic mark extensively altered in cancer, is also linked to genome architecture and function. Based on this association, we postulate that the dissection of long-range co-methylation structure unveils cancer cell’s genome architecture remodeling.We applied network-modeling of DNA methylation co-variation in two colon cancer cohorts and found abundant and consistent transchromosomal structures in both normal and tumor tissue. Normal-tumor comparison indicated substantial remodeling of the epigenome covariation and revealed novel genomic compartments with a unique signature of DNA methylation rank inversion.

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