Sa1052 IN-VITRO EVALUATION OF ANTIFOAMING EFFECTS OF SIMETHICONE: A DOSE-FINDING STUDY

2019 ◽  
Vol 89 (6) ◽  
pp. AB156 ◽  
Author(s):  
Marguerite Kutyla ◽  
Ayesha Shah ◽  
Vera Meeusen ◽  
Jerome Elson ◽  
Alex Heulsen-Katz ◽  
...  
Keyword(s):  
Dose Finding ◽  
In Vitro Evaluation ◽  
Finding Study ◽  
Dose Finding Study

scholarly journals A norfloxacin dose finding study for selective decontamination of the digestive tract in pigs

1989 ◽  
Vol 102 (1) ◽  
pp. 93-103 ◽  
Author(s):  
L. A. Van Der Waaij ◽  
O. Messerschmidt ◽  
D. Van Der Waaij
Keyword(s):  
Digestive Tract ◽  
Selective Decontamination ◽  
Dose Finding ◽  
Substantial Part ◽  
Substantial Fraction ◽  
Intestinal Contents ◽  
Finding Study ◽  
Dose Finding Study

SUMMARYFive pigs were treated orally with norfloxacin for 5 consecutive days in two well-separated periods. This was done to determine the lowest dose required to free the pigs of Enterobacteriaceae. In the first period of the study, the animals were treated with 400 mg per day while in the second treatment 800 mg norfloxacin was given. Daily faecal culturing indicated that the faeces became free of Enterobacteriaceae in 3–5 days when treated with 400 mg/day, while all animals were found negative on culturing after 3 days of treatment with 800 mg/day. Investigation of the concentration of norfloxacin in the faeces revealed that a substantial fraction of the dose was either absorbed or inactivated by faecal substances. An in vitro study in faeces confirmed that a substantial part, some 75% of the dose, may have been inactivated by intestinal contents. This finding helps to explain the much lower concentration of 120 mg norfloxacin per kg of faeces in the pig in comparison with the almost tenfold higher concentration reported to develop in man during treatment with an identical dose.

An in vitro and clinical dose-finding study of antifoaming effects of simethicone during colonoscopy

2019 ◽  
Vol 38 (3) ◽  
pp. 268-272 ◽  
Author(s):  
Marguerite J. Kutyla ◽  
Ayesha Shah ◽  
Jerome Elson ◽  
Vera Meeusen ◽  
Sam O’Connor ◽  
...  
Keyword(s):  
Dose Finding ◽  
Clinical Dose ◽  
Finding Study ◽  
Dose Finding Study

scholarly journals Correction to: An in vitro and clinical dose-finding study of antifoaming effects of simethicone during colonoscopy

2019 ◽  
Vol 38 (6) ◽  
pp. 557-557
Author(s):  
Marguerite J. Kutyla ◽  
Ayesha Shah ◽  
Jerome Elson ◽  
Vera Meeusen ◽  
Sam O’Connor ◽  
...  
Keyword(s):  
Dose Finding ◽  
Clinical Dose ◽  
Finding Study ◽  
Dose Finding Study
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