Continuous supply of the neurotrophins BDNF and NT‐3 improve chick motor neuron survival in vivo

2004 ◽  
Vol 23 (4) ◽  
pp. 389-396 ◽  
Author(s):  
Andrew Gibbons ◽  
Nigel Wreford ◽  
Jacinta Pankhurst ◽  
Karen Bailey
Keyword(s):  
Motor Neuron ◽  
Neuron Survival ◽  
Motor Neuron Survival

scholarly journals LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice

2019 ◽  
Vol 27 (4) ◽  
pp. 1369-1382 ◽  
Author(s):  
Honglin Tan ◽  
Mina Chen ◽  
Dejiang Pang ◽  
Xiaoqiang Xia ◽  
Chongyangzi Du ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Neuron ◽  
Motor Neurons ◽  
Neuronal Survival ◽  
Disease Onset ◽  
Alternative Mechanism ◽  
Specific Expression ◽  
Motor Neuron Survival ◽  
Lateral Sclerosis

Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive loss of motor neurons. Improving neuronal survival in ALS remains a significant challenge. Previously, we identified Lanthionine synthetase C-like protein 1 (LanCL1) as a neuronal antioxidant defense gene, the genetic deletion of which causes apoptotic neurodegeneration in the brain. Here, we report in vivo data using the transgenic SOD1G93A mouse model of ALS indicating that CNS-specific expression of LanCL1 transgene extends lifespan, delays disease onset, decelerates symptomatic progression, and improves motor performance of SOD1G93A mice. Conversely, CNS-specific deletion of LanCL1 leads to neurodegenerative phenotypes, including motor neuron loss, neuroinflammation, and oxidative damage. Analysis reveals that LanCL1 is a positive regulator of AKT activity, and LanCL1 overexpression restores the impaired AKT activity in ALS model mice. These findings indicate that LanCL1 regulates neuronal survival through an alternative mechanism, and suggest a new therapeutic target in ALS.

scholarly journals Hsp27 Upregulation and Phosphorylation Is Required for Injured Sensory and Motor Neuron Survival

Neuron ◽  
2002 ◽  
Vol 36 (1) ◽  
pp. 45-56 ◽  
Author(s):  
Susanna C. Benn ◽  
Daniel Perrelet ◽  
Ann C. Kato ◽  
Joachim Scholz ◽  
Isabelle Decosterd ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Neuron Survival ◽  
Motor Neuron Survival

Altered astrocytic expression of TDP-43 does not influence motor neuron survival

2013 ◽  
Vol 250 ◽  
pp. 250-259 ◽  
Author(s):  
Amanda M. Haidet-Phillips ◽  
Sarah K. Gross ◽  
Timothy Williams ◽  
Alisha Tuteja ◽  
Alex Sherman ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Neuron Survival ◽  
Motor Neuron Survival

scholarly journals Author response: The critical role of membralin in postnatal motor neuron survival and disease

2015 ◽  
Author(s):  
Bo Yang ◽  
Mingliang Qu ◽  
Rengang Wang ◽  
Jon E Chatterton ◽  
Xiao-Bo Liu ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Critical Role ◽  
Author Response ◽  
Neuron Survival ◽  
Motor Neuron Survival
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