Development of a tablet press feed frame lead lag determination model using in-line and off-line NIR measurements

2021 ◽  
pp. 121284
Author(s):  
Daan Van Hauwermeiren ◽  
Michiel Peeters ◽  
Elisabeth Peeters ◽  
Giuseppi Cogoni ◽  
Liu A. Yang ◽  
...  
Keyword(s):  
Tablet Press

scholarly journals Blend Segregation in Tablets Manufacturing and Its Effect on Drug Content Uniformity—A Review

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1909
Author(s):  
Emilia Jakubowska ◽  
Natalia Ciepluch
Keyword(s):  
Active Pharmaceutical Ingredient ◽  
Content Uniformity ◽  
Continuous Manufacturing ◽  
Compression Process ◽  
Factors Affecting ◽  
Die Filling ◽  
Drug Potency ◽  
Tablet Press ◽  
Tablet Manufacturing ◽  
Processing Factors

Content uniformity (CU) of the active pharmaceutical ingredient is a critical quality attribute of tablets as a dosage form, ensuring reproducible drug potency. Failure to meet the accepted uniformity in the final product may be caused either by suboptimal mixing and insufficient initial blend homogeneity, or may result from further particle segregation during storage, transfer or the compression process itself. This review presents the most relevant powder segregation mechanisms in tablet manufacturing and summarizes the currently available, up-to-date research on segregation and uniformity loss at the various stages of production process—the blend transfer from the bulk container to the tablet press, filling and discharge from the feeding hopper, as well as die filling. Formulation and processing factors affecting the occurrence of segregation and tablets’ CU are reviewed and recommendations for minimizing the risk of content uniformity failure in tablets are considered herein, including the perspective of continuous manufacturing.

Deformation behavior of crystallized mannitol during compression using a rotary tablet press simulator

2018 ◽  
Vol 547 (1-2) ◽  
pp. 142-149 ◽  
Author(s):  
Nicolas Tarlier ◽  
Ian Soulairol ◽  
Noelia Sanchez-Ballester ◽  
Gilles Baylac ◽  
Adrien Aubert ◽  
...  
Keyword(s):  
Deformation Behavior ◽  
Tablet Press

Computer Interfaced Instrumentation of a Rotary Tablet Press

1985 ◽  
Vol 11 (1) ◽  
pp. 83-100 ◽  
Author(s):  
D. A. D'stefan ◽  
G. D. Leesman ◽  
M. R. Patel ◽  
W. T. Morehead
Keyword(s):  
Tablet Press
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