scholarly journals IMPROVEMENTS IN EMOTIONAL LABILITY WITH DELAYED-RELEASE AND EXTENDED-RELEASE METHYLPHENIDATE TREATMENT IN CHILDREN WITH ADHD

2021 ◽  
Vol 60 (10) ◽  
pp. S257
Author(s):  
Valerie Arnold ◽  
Frank Lopez ◽  
Ann Childress ◽  
Michelle Po ◽  
Ryan Gregg ◽  
...  
Keyword(s):  
Extended Release ◽  
Emotional Lability ◽  
Children With Adhd ◽  
Delayed Release

scholarly journals Clinically Meaningful Improvements in Early Morning and Late Afternoon/Evening Functional Impairment in Children with ADHD Treated with Delayed-Release and Extended-Release Methylphenidate

2021 ◽  
pp. 108705472110200
Author(s):  
Timothy E. Wilens ◽  
Stephen V. Faraone ◽  
Paul G. Hammerness ◽  
Steven R. Pliszka ◽  
Cassandra L. Uchida ◽  
...  
Keyword(s):  
Functional Impairment ◽  
Extended Release ◽  
Early Morning ◽  
Operating Characteristics ◽  
Parent Rating ◽  
Children With Adhd ◽  
Late Afternoon ◽  
Delayed Release ◽  
Before School ◽  
Post Hoc

Objective: The Before School Functioning Questionnaire and Parent Rating of Evening and Morning Behavior–Revised assess early morning (BSFQ, PREMB-R AM subscale) and late afternoon/evening (PREMB-R PM subscale) functional impairment in children with ADHD. Clinically meaningful improvements were identified and applied to a trial of delayed-release and extended-release methylphenidate (DR/ER-MPH) in children with ADHD (NCT02520388) to determine if the statistically-determined improvements in functional impairment were also clinically meaningful. Method: Clinically meaningful improvements in BSFQ/PREMB-R were established post hoc by receiver operating characteristics curves, using anchors of Clinical Global Impression–Improvement (CGI-I) = 1 and CGI-I ≤ 2. Percentages of participants achieving these thresholds were calculated. Results: Thresholds for CGI-I = 1/CGI-I ≤ 2, respectively, were 27/20 (BSFQ), 5/3 (PREMB-R AM), and 9/5 (PREMB-R PM)-point decreases. More children achieved clinically meaningful improvements with DR/ER-MPH versus placebo (all p < .05). Conclusion: DR/ER-MPH increased proportions of children achieving clinically meaningful improvements in BSFQ and PREMB-R.

5.12 ELECTRONICALLY MONITORED ADHERENCE RATES WITH EVENING-DOSED DELAYED-RELEASE AND EXTENDED-RELEASE METHYLPHENIDATE IN CHILDREN WITH ADHD

2020 ◽  
Vol 59 (10) ◽  
pp. S152-S153
Author(s):  
Ann Catherine Childress ◽  
Steven R. Pliszka ◽  
Andrew J. Cutler ◽  
Andrea Marraffino ◽  
Norberto J. DeSousa ◽  
...  
Keyword(s):  
Extended Release ◽  
Children With Adhd ◽  
Delayed Release

6.48 CLINICAL RESPONSES AND SYMPTOMATIC REMISSIONS ACHIEVED WITH DELAYED-RELEASE AND EXTENDED-RELEASE METHYLPHENIDATE IN CHILDREN WITH ADHD

2019 ◽  
Vol 58 (10) ◽  
pp. S286-S287
Author(s):  
Ann C. Childress ◽  
Sharon B. Wigal ◽  
Andrea Marraffino ◽  
Norberto J. DeSousa ◽  
Bev Incledon ◽  
...  
Keyword(s):  
Extended Release ◽  
Children With Adhd ◽  
Delayed Release ◽  
Clinical Responses

5.21 POST HOC META-ANALYSIS OF MORNING AND EVENING BEHAVIORS IN CHILDREN WITH ADHD TREATED WITH DELAYED-RELEASE AND EXTENDED-RELEASE METHYLPHENIDATE FROM TWO PHASE 3 STUDIES

2020 ◽  
Vol 59 (10) ◽  
pp. S155-S156
Author(s):  
Steven R. Pliszka ◽  
Ann Catherine Childress ◽  
Andrew J. Cutler ◽  
Andrea Marraffino ◽  
Norberto J. DeSousa ◽  
...  
Keyword(s):  
Extended Release ◽  
Meta Analysis ◽  
Phase 3 ◽  
Two Phase ◽  
Children With Adhd ◽  
Delayed Release ◽  
Post Hoc

31.8 REAL-WORLD SAFETY PROFILE OF DELAYED-RELEASE AND EXTENDED-RELEASE METHYLPHENIDATE FOR ADHD IN CHILDREN, ADOLESCENTS, AND ADULTS

2020 ◽  
Vol 59 (10) ◽  
pp. S213
Author(s):  
Ann Catherine Childress ◽  
Victor Otcheretko ◽  
Lewis E. Warrington ◽  
Justin A. Barnes ◽  
Ryan A. Gregg ◽  
...  
Keyword(s):  
Real World ◽  
Safety Profile ◽  
Extended Release ◽  
Delayed Release ◽  
Adolescents And Adults
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