Methaemoglobin results from the oxidation of ferrous to ferric iron in
the centre of the haem moeity of haemoglobin. The production of
dose-dependent methaemoglobinaemia by 8-aminoquinoline antimalarial
drugs appears to be associated with, but is not directly linked to
therapeutic efficacy against latent vivax and ovale malarias. Iatrogenic
methaemoglobinaemia may be a useful pharmacodynamic measure in
8-aminoquinoline drug and dose optimization.
In this study, we found that linezolid combined with fosfomycin could kill
Enterococcus in vitro
and that the administered dose was significantly lower after the combination treatment, which could reduce adverse effects and the development of drug resistance. The potential mechanism of the two-drug combination against
Enterococcus
was revealed from a quantitative perspective, which is an important step toward dose optimization in simulated humans.