Bonding Strength of Lithium Disilicate Adhesive Crowns with Different Occluso-Cervical Preparation Heights and Cement Types

The aim of this study was to evaluate if adhesion technology with CAD/CAM can compensate for the reduction of occluso cervical preparation heights using different types of dental cement. The de-bonding failure types were then assessed. Here, 72 caries-free extracted human premolar teeth were prepared to have a remaining occlusal height of two, three, and four mm. IPS e.max lithium disilicate CAD/CAM crowns were cemented with adhesive resin cement Panavia SA, self-adhesive resin cement, RelyX Unicem Aplicap, and zinc phosphate cement. The cementation techniques were based on the manufacturer’s instructions. After thermocycling, all samples were tested for tensile bond strength via an Instron machine. One-way analysis of variance (ANOVA) with post hoc testing (P < 0.05) was performed. The means TBS for the two, three, and four-mm OCHP groups were 2.72±0.69, 3.06±0.82, and 3.25±0.79.0 MPa; ARC, SARC, and ZPC were 3.41±0.51, 3.45±0.41, 2.08±0.35 MPa, respectively with significant differences in both. The mixed cement had failures in the resin cement groups. Failure was predominantly cohesive in the zinc phosphate group. Resin cement had the highest SBS values versus ZPC values when both bonded to lithium disilicate crowns with different occlusal heights. The failure of the adhesive to the crown and/or to the tooth were the highest for the four types of resin cement. Around 25% were cohesive failures with resin cement, but this was predominately adhesive in crowns in zinc phosphate regardless of the preparation heights.

Tracking Anthropomorphizing Behavior in Human-Robot Interaction

Existing methodologies to describe anthropomorphism in human-robot interaction often rely either on specific one-time responses to robot behavior, such as keeping the robot's secret, or on post hoc measures, such as questionnaires. Currently, there is no method to describe the dynamics of people's behavior over the course of an interaction and in response to robot behavior. In this paper, I propose a method that allows the researcher to trace anthropomorphizing and non-anthropomorphizing responses to robots dynamically moment-by-moment over the course of human-robot interactions. I illustrate this methodology in a case study and find considerable variation between participants, but also considerable intrapersonal variation in the ways the robot is anthropomorphized. That is, people may respond to the robot as if it was another human in one moment and to its machine-like properties in the next. These findings may influence explanatory models of anthropomorphism.

Rubiadin exerts an acute and chronic anti-inflammatory effect in rodents

Rubiadin is identified as a bioactive anthraquinone that exists in some quinone rich plants. The current research was carried out to evaluate the potential anti-inflammatory impact of Rubiadin in acute and chronic inflammation test models in rodents. The anti-inflammatory activity of Rubiadin was examined in cotton pellet-induced granuloma and carrageenan-induced edema as chronic and acute inflammation models in rats. TNF-α level and histopathological changes were assessed using sampled foot tissue of rat in the acute model. Also, the IL-1β level was assessed in the chronic model. One-way ANOVA (post hoc Tukey’s) analysis was used for comparing the groups. Rubiadin (0.5 mg/kg, i.p.) induced a significant reduction in TNF α level and the paw edema compared to the control group in carrageenan test. Also, it was observed that the anti-inflammatory activity of Rubiadin (0.5 mg/kg, i.p.) is comparable to mefenamic acid (30 mg/kg, i.p.) as the standard drug. Rubiadin was effective in granuloma induced by cotton pellet concerning the granuloma and transudate formation amount. Rubiadin’s anti-inflammatory effects were associated with a significant IL-1β decrease in this model. The results suggest that Rubiadin as a natural compound can possess significant peripheral anti-inflammatory impacts.

Assessing Students’ Approaches and Perceptions to Learning in Physics Experiments Based on Simulations and At-Home Lab Kits

Our study evaluates students&rsquo; approaches to and perceptions of the use of hands-on at-home laboratory kits (HALK) experiments, open-source computer-based simulations (OSCBS), and their combination (OSCBS-HALK) in undergraduate introductory asynchronous online physics courses. Anonymous survey data from students who had completed online physics courses with labs based on simulations, at-home lab kits, or both were collected using a modified version of the Learn Questionnaire (MVLQ). Findings in this study indicate that among the six scales (interest and relevance; peer support; staff enthusiasm and support; teaching for understanding; alignment; and constructive feedback) used to measure students&rsquo; perceptions of the teaching and learning environments, interest and relevance, peer support, and teaching for understanding had statistically significant different means across the three lab types. Post-hoc comparisons using the Tukey HSD test for the interest and relevance scale indicated that students viewed using a combination approach of OSCBS and HALK labs (M = 3.98, SD = 0.61) more significantly positive than using computer-simulated labs only (M = 3.56, SD = 0.75). Compared to other labs, computer-simulated labs were perceived to lead to a deep approach to learning. However, they had the lowest interest and relevance, peer support, and alignment ranking among the three lab groups. Thus, developing strategies to improve students&rsquo; engagement and ability to translate the simulations into physical processes is recommended for OSCBS.

Association between Levocarnitine Treatment and the Change in Knee Extensor Strength in Patients Undergoing Hemodialysis: A Post-Hoc Analysis of the Osaka Dialysis Complication Study (ODCS)

Carnitine deficiency is prevalent in patients undergoing hemodialysis, and it could result in lowered muscle strength. So far, the effect of treatment with levocarnitine on lower limb muscle strength has not been well described. This observational study examined the association between treatment with levocarnitine with the change in knee extensor strength (KES) in hemodialysis patients. Eligible patients were selected from the participants enrolled in a prospective cohort study for whom muscle strength was measured annually. We identified 104 eligible patients for this analysis. During the one-year period between 2014 to 2015, 67 patients were treated with intravenous levocarnitine (1000 mg per shot, thrice weekly), whereas 37 patients were not. The change in KES was significantly higher (p = 0.01) in the carnitine group [0.02 (0.01–0.04) kgf/kg] as compared to the non-carnitine group [−0.02 (−0.04 to 0.01) kgf/kg]. Multivariable-adjusted regression analysis showed the positive association between the change in KES and the treatment with levocarnitine remained significant after adjustment for the baseline KES and other potential confounders. Thus, treatment with intravenous levocarnitine was independently and positively associated with the change in KES among hemodialysis patients. Further clinical trials are needed to provide more solid evidence.