Subcorneal pustular dermatosis (SPD) is a rare, chronic, recurrent, pustular eruption. It may
be difficult to differentiate SPD from Acute Generalized Exanthematous Pustulosis (AGEP) and
Generalized Pustular Psoriasis (GPP)just from clinical appeareance. A 48 years old woman with
subcorneal pustular dermatosis was reported. She was complained there were tiny blisters containing pus
on the reddish patches that felt burning and became widespread to neck, chest, abdomen, arms, groin and
legs since 4 days ago. Patient had no history of skin lesion before. From physical examination revealed
no other pathologies and on the skin showed erythematous patches with annular lesion, pustules
formation that tended to coalesce to form desquamative plaques, erosions, on chest, abdomen, back, arm,
buttock and leg. Based on histopathology showed there are subcorneal pustules. The subcorneal pustule
is filled with neutrophils and on the dermis, there are mild infiltration of neutrophil cells. This feature
revealed to SPD.Clinically it may be difficult to differentiate SPD from AGEP and GPP. Histopathology
examination can distinguished these disease,patient was treated with prednisone 40 mg and dapson 100
mg and had improvement after 4 weeks.
Paracetamol Induced Acute Generalized Exanthematous Pustulosis- A Rare Case Report
