Serum cortisol and adrenocorticotrophic hormone (ACTH) in infants receiving topical ocular corticosteroids following cataract surgery

An eight-year-old, female, neutered labradoodle was presented for investigation of a three-week history of lethargy and regurgitation. Two sets of conscious thoracic radiographs, performed approximately two weeks apart, revealed the presence of megaoesophagus. Serum cortisol concentration (pre-adrenocorticotrophic hormone (ACTH) and post-ACTH stimulation), serum aldosterone concentration post-ACTH stimulation and plasma endogenous ACTH concentration confirmed the diagnosis of isolated glucocorticoid-deficient hypoadrenocorticism. Following glucocorticoid supplementation, rapid resolution of the clinical signs was reported, and repeated conscious thoracic radiographs one week later showed complete resolution of the megaoesophagus.

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Retrobulbar block fails to prevent an increase in serum cortisol concentration on emergence from anaesthesia after cataract surgery

British Journal of Anaesthesia ◽

10.1093/bja/73.1.120 ◽

1994 ◽

Vol 73 (1) ◽

pp. 120

Author(s):

S.J. SEDDON

Keyword(s):

Cataract Surgery ◽

Serum Cortisol ◽

Cortisol Concentration ◽

Retrobulbar Block ◽

Serum Cortisol Concentration

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Transient pituitary hypothyroidism in a patient with ectopic adrenocorticotrophic hormone secretion

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1258/0004563001899438 ◽

2000 ◽

Vol 37 (3) ◽

pp. 298-303 ◽

Cited By ~ 2

Author(s):

J Rodríguez-Espinosa ◽

E Urgell ◽

J Montesinos ◽

P D Omingo ◽

S M Webb

Keyword(s):

Small Cell Lung Carcinoma ◽

Hormone Secretion ◽

Serum Cortisol ◽

Thyroid Stimulating Hormone ◽

Independent Effect ◽

Thyroid Function Tests ◽

Adrenocorticotrophic Hormone ◽

Cell Lung Carcinoma ◽

Factor Α ◽

Serum Tsh

We report the case of a 55-year-old woman who presented with hypercortisolism secondary to ectopic adrenocorticotrophic hormone secretion and severe non-thyroidal illness syndrome (NTIS) due to metastatic small cell lung carcinoma associated with severe infections. The patient initially showed hormonal profiles of pituitary hypothyroidism and gonadal hypofunction. After decrease in cortisol production following treatment with chemotherapy and metyrapone, serum thyroid hormones and thyroid-stimulating hormone (TSH) concentrations normalized. Study of the relative contributions of cortisol and pro-inflammatory cytokines (interleukin-6 and tumour necrosis factor α) to the overall variability in thyroid function tests disclosed a significant and independent effect of serum cortisol on serum TSH concentrations; the variability in free thyroid hormone concentration was explained only by changes in TSH concentration. These observations indicate that cortisol could be the major determinant of changes in serum TSH concentrations in clinical conditions accompanied by hypercortisolism, as occurs in NTIS.

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