Low serum cortisol in combination with high adrenocorticotrophic hormone concentrations are associated with poor outcome in children with severe meningococcal disease

2002 ◽  
Vol 21 (4) ◽  
pp. 330-336 ◽  
Author(s):  
ESTER D. DE KLEIJN ◽  
KOEN F. M. JOOSTEN ◽  
BOUKJE VAN RIJN ◽  
MARINKE WESTERTERP ◽  
RONALD DE GROOT ◽  
...  
Keyword(s):  
Meningococcal Disease ◽  
Serum Cortisol ◽  
Adrenocorticotrophic Hormone ◽  
Poor Outcome ◽  
Low Serum

scholarly journals Low serum albumin and positive lymph nodes predict poor outcome in cholangiocarcinoma

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e672-e673
Author(s):  
M.A. Gani ◽  
J. Watt ◽  
L. Solaini ◽  
P. Arumugam ◽  
R. Hutchins ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Lymph Nodes ◽  
Poor Outcome ◽  
Positive Lymph Nodes ◽  
Low Serum

Reversible megaoesophagus in a dog with isolated glucocorticoid-deficient hypoadrenocorticism

2020 ◽  
Vol 8 (1) ◽  
pp. e001055
Author(s):  
Darren Kelly
Keyword(s):  
Complete Resolution ◽  
Clinical Signs ◽  
Serum Cortisol ◽  
Cortisol Concentration ◽  
Adrenocorticotrophic Hormone ◽  
Acth Stimulation ◽  
Serum Aldosterone ◽  
History Of ◽  
Acth Concentration ◽  
Serum Cortisol Concentration

An eight-year-old, female, neutered labradoodle was presented for investigation of a three-week history of lethargy and regurgitation. Two sets of conscious thoracic radiographs, performed approximately two weeks apart, revealed the presence of megaoesophagus. Serum cortisol concentration (pre-adrenocorticotrophic hormone (ACTH) and post-ACTH stimulation), serum aldosterone concentration post-ACTH stimulation and plasma endogenous ACTH concentration confirmed the diagnosis of isolated glucocorticoid-deficient hypoadrenocorticism. Following glucocorticoid supplementation, rapid resolution of the clinical signs was reported, and repeated conscious thoracic radiographs one week later showed complete resolution of the megaoesophagus.

scholarly journals Low Serum Cortisol in Term Newborns With Refractory Hypotension

1999 ◽  
Vol 19 (5) ◽  
pp. 352-357 ◽  
Author(s):  
Phuket Tantivit ◽  
Nirupama Subramanian ◽  
Meena Garg ◽  
Rangasamy Ramanathan ◽  
Robert A deLemos
Keyword(s):  
Serum Cortisol ◽  
Refractory Hypotension ◽  
Term Newborns ◽  
Low Serum

Therapy With Steroid-Containing Regimens in Myeloma Patients Can Result in Significantly Low Serum Cortisol Levels

2019 ◽  
Vol 19 (10) ◽  
pp. e252 ◽  
Author(s):  
Mark Cook ◽  
Guy Pratt ◽  
Rebecca Powell ◽  
Andrew Toogood
Keyword(s):  
Serum Cortisol ◽  
Cortisol Levels ◽  
Low Serum

scholarly journals The Association of Low Blood Glucose and Low Serum Cortisol Levels in Severely Ill Children Admitted to Tertiary Referral Hospitals in Malawi: A Case-Control Study

2021 ◽  
Author(s):  
Fatsani Ngwalangwa ◽  
Clifford Katumbi ◽  
Queen Dube ◽  
Josephine Langton ◽  
Tim Baker ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Adrenal Insufficiency ◽  
Case Control Study ◽  
Serum Cortisol ◽  
Case Control ◽  
Cortisol Levels ◽  
Low Cortisol ◽  
Blood Glucose Concentrations ◽  
Control Study ◽  
Low Serum

Low blood glucose concentrations (< 5 mmol/L) in severely ill children presenting to hospitals in low-income countries are associated with mortality. Adrenal insufficiency with low cortisol levels may contribute to low blood glucose concentrations. Understanding the association between low cortisol and low blood glucose may assist in improving guidelines for management of severely ill children. The study aimed to determine the association between low serum cortisol and low blood glucose in severely ill children. A matched case-control study of children aged 1 month to 15 years was conducted at two tertiary hospitals in Malawi. Cases were children with blood glucose <5 mmol/L. Two age-matched controls with blood glucose of ≥5–15 mmol/L were enrolled per case. Low cortisol was defined as serum cortisol of <25 µg/dL (690 nmol/L) and adrenal insufficiency as serum cortisol of <10 µg/dL (276 nmol/L). A total of 54 cases and 108 controls were enrolled with, median age of 2.8 years (interquartile range [IQR]: 1.7–4.4). The median cortisol level was 58.7 µg/dL (IQR: 42.3–61.8) in cases and 40.9 µg/dL (IQR: 33.7–51.2) in controls (P = 0.911). The proportion of low cortisol was 4/54 (7.4%) in cases and 9/108 (8.3%) in controls. Logistic regression shows no association between low cortisol and low blood glucose (adjusted odds ratio: 0.33; 95% confidence interval, 0.04–3.02). Results suggest that there is no association between low cortisol and low blood glucose among severely ill children presenting to hospitals in Malawi. The reason for low blood glucose needs further investigation.

scholarly journals Prognostic significance of serum cortisol and serum albumin in patients of ischemic stroke

2020 ◽  
Vol 7 (4) ◽  
pp. 650
Author(s):  
Saman Fatima ◽  
Ruhi Khan
Keyword(s):  
Ischemic Stroke ◽  
Serum Albumin ◽  
Prognostic Significance ◽  
Serum Cortisol ◽  
Prognostic Indicators ◽  
Medical College ◽  
Good Outcome ◽  
Poor Outcome ◽  
Observational Cohort ◽  
The Mean

Background: Stroke is the second most common cause of mortality worldwide and a major contributor to morbidity and chronic adult disability. To study the prognostic significance of serum cortisol and serum albumin in patients of ischemic stroke was the objective.Methods: This hospital based observational cohort prospective study was undertaken in the Department of Medicine in collaboration with the Departments of Radio diagnosis and Pathology, Jawahar Lal Nehru Medical College and Hospital, AMU, Aligarh from January 2017 to November 2018. By convenience method for sampling, 102 patients who were admitted with the diagnosis of acute ischemic stroke to IPD of JNMCH, Aligarh, on clinical as well as radiological grounds were taken into study.Results: Mean cortisol was 450.84±190.35 nmol/L. The (mean±SD) of serum cortisol was 258.10±77.91 ng/ml in patients with good outcome and 585.77±113.34ng/ml in patients with poor outcome. (p<0.05, r= 0.812). Mean serum albumin was 2.83±0.76 gm/dl. The (mean±SD) of serum albumin was 3.47±0.64mg/dl in patients with good outcome and it was comparatively lower in patients with poor outcome (2.38±0.45mg/dl).  (p <0.01, r=-0.659).Conclusions: Serum albumin, serum cortisol are prognostic indicators of functional outcome at 3 months in patients of ischemic stroke.

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