scholarly journals Electrophysiologic Remodeling of the Left Ventricle in Pressure Overload-Induced Right Ventricular Failure

2012 ◽  
Vol 59 (24) ◽  
pp. 2193-2202 ◽  
Author(s):  
Maxim Hardziyenka ◽  
Maria E. Campian ◽  
Arie O. Verkerk ◽  
Sulaiman Surie ◽  
Antoni C.G. van Ginneken ◽  
...  
2020 ◽  
Vol 26 (10) ◽  
pp. S128
Author(s):  
Kathir Balakumaran ◽  
Raul Angel Garcia ◽  
Tracy Schwab ◽  
Safwan Gaznabi ◽  
Jennifer T. Dahm ◽  
...  

2017 ◽  
Vol 7 (3) ◽  
pp. 572-587 ◽  
Author(s):  
Nolwenn Samson ◽  
Roxane Paulin

Right ventricular failure (RVF) is the most important prognostic factor for both morbidity and mortality in pulmonary arterial hypertension (PAH), but also occurs in numerous other common diseases and conditions, including left ventricle dysfunction. RVF remains understudied compared with left ventricular failure (LVF). However, right and left ventricles have many differences at the morphological level or the embryologic origin, and respond differently to pressure overload. Therefore, knowledge from the left ventricle cannot be extrapolated to the right ventricle. Few studies have focused on the right ventricle and have permitted to increase our knowledge on the right ventricular-specific mechanisms driving decompensation. Here we review basic principles such as mechanisms accounting for right ventricle hypertrophy, dysfunction, and transition toward failure, with a focus on epigenetics, inflammatory, and metabolic processes.


2011 ◽  
Vol 57 (8) ◽  
pp. 921-928 ◽  
Author(s):  
Maxim Hardziyenka ◽  
Maria E. Campian ◽  
Herre J. Reesink ◽  
Sulaiman Surie ◽  
Berto J. Bouma ◽  
...  

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Todd L. Kiefer ◽  
Thomas M. Bashore

Pulmonary hypertension (PH) is the end result of a variety of diverse pathologic processes. The chronic elevation in pulmonary artery pressure often leads to right ventricular pressure overload and subsequent right ventricular failure. In patients with left-sided cardiac disease, PH is quite common and associated with increased morbidity and mortality. This article will review the literature as it pertains to the epidemiology, pathogenesis, and diagnosis of PH related to aortic valve disease, mitral valve disease, left ventricular systolic and diastolic dysfunction, and pulmonary veno-occlusive disease. Moreover, therapeutic strategies, which focus on treating the underlying cardiac pathology will be discussed.


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