The Combination Product Captisol-Enabled® Budesonide + Azelastine HCl Nasal Spray Provides Significant, Long-lasting Relief of Ocular Allergy Symptoms in Ragweed Allergic Patients Studied in an Environmental Exposure Chamber (EEC)

2009 ◽  
Vol 123 (2) ◽  
pp. S130-S130
Author(s):  
P. Patel ◽  
A. Salapatek ◽  
P. D'Angelo ◽  
M. Bates ◽  
D. Patel ◽  
...  
Keyword(s):  
Environmental Exposure ◽  
Nasal Spray ◽  
Exposure Chamber ◽  
Ocular Allergy ◽  
Combination Product ◽  
Environmental Exposure Chamber

Onset of Action of Azelastine Nasal Spray Compared with Mometasone Nasal Spray and Placebo in Subjects with Seasonal Allergic Rhinitis Evaluated in an Environmental Exposure Chamber

2007 ◽  
Vol 21 (4) ◽  
pp. 499-503 ◽  
Author(s):  
Piyush Patel ◽  
Carrie D'Andrea ◽  
Harry J. Sacks
Keyword(s):  
Allergic Rhinitis ◽  
Environmental Exposure ◽  
Nasal Spray ◽  
Seasonal Allergic Rhinitis ◽  
Allergen Challenge ◽  
Nasal Symptom ◽  
Exposure Chamber ◽  
Onset Of Action ◽  
Environmental Exposure Chamber ◽  
Time Point

Background The objective of this study was to determine the onset of action of azelastine hydrochloride nasal spray compared with placebo and an intranasal steroid, mometasone furoate, in subjects with seasonal allergic rhinitis (SAR). Methods Subjects with a history of SAR and symptomatic while exposed to ragweed pollen in an environmental exposure chamber (EEC) were randomized to azelastine nasal spray (n = 150), mometasone nasal spray (n = 150), or placebo (n = 150) and recorded total nasal symptom scores (TNSS), consisting of sneezing, nasal pruritus, rhinorrhea, and congestion, during an 8-hour study period. Results Azelastine nasal spray showed a statistically significant improvement in the TNSS at 15 minutes compared with placebo. The effect was durable at each time point during the 8-hour study. Azelastine nasal spray also was significantly more effective than mometasone at each time point. Conclusion Azelastine nasal spray has a rapid (15 minute) onset of action. Azelastine nasal spray was superior to both placebo and mometasone nasal spray in reducing nasal symptoms of SAR occurring within 8 hours after an allergen challenge.

Onset and dose-related efficacy of house dust mite sublingual immunotherapy tablets in an environmental exposure chamber

2015 ◽  
Vol 135 (6) ◽  
pp. 1494-1501.e6 ◽  
Author(s):  
Hendrik Nolte ◽  
Jennifer Maloney ◽  
Harold S. Nelson ◽  
David I. Bernstein ◽  
Susan Lu ◽  
...  
Keyword(s):  
Environmental Exposure ◽  
House Dust ◽  
House Dust Mite ◽  
Sublingual Immunotherapy ◽  
Exposure Chamber ◽  
Dust Mite ◽  
Environmental Exposure Chamber
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