Fixed Drug Eruptions Secondary to Fixed Drug Combination (ofloxacin/ornidazole): A Cross Sensitivity Case Report

Background: Fixed drug eruption (FDE) is an erythematous cutaneous patch caused by certain drugs through activation of immunologic reaction in the body. The onset of FDE is 30 minutes to 8 hours and is estimated to occur upto 16-21% of all cutaneous reactions. The irrational combination of fluoroquinolones and nitroimidazole is the most prescribed drug for diarrhea in India, and the drug is found to cause FDE either individually or in combination. Cross sensitivity is the major issue associated with Fluoroquinolones and nitroimidazole. Case repor: Our case is of a 45-year-old male who developed FDE due to a combination product of ofloxacin and ornidazole with past FDE history due to a combination product of norfloxacin and tinidazole. The patient presented with erythematous patches all over the body, swollen lips, mucosal erosion over the buccal cavity, and glans penis. Discussion: The patient was successively treated after the withdrawal of the culprit drug with oral Antihistamines, corticosteroids, and other topical creams and gels, which correlates with the standard management of FDE. Conclusion: Proper prescribing knowledge, documentation of drug allergies, and educating patient about allergic reaction play vital role to prevent future drug related problems.

Field study to investigate the effectiveness and safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio® Plus) for the prevention of heartworm disease (Dirofilaria immitis) in client-owned dogs in the USA

Background Dirofilaria immitis, a globally distributed filarial parasite of dogs, is known to cause serious or fatal cardiopulmonary disease. Client-owned dogs were enrolled in a clinical field study in the USA to evaluate the clinical effectiveness and field safety of an orally administered combination investigational product (IP) containing milbemycin oxime and lotilaner (Credelio® Plus) as compared to a control product (CP) for the prevention of heartworm disease when administered monthly for 11 consecutive months. Methods In this 11-month field study, 319 dogs ≥ 8 weeks old confirmed to be heartworm-negative were enrolled from eight geographically distinct US veterinary clinics, including sites in the southern USA and Mississippi River Valley. The dogs were treated with either the IP combination product at 0.75–1.53 mg/kg milbemycin oxime and 20–41.5 mg/kg lotilaner (n = 159) or the CP (Sentinel® Flavor Tabs®; milbemycin oxime/lufenuron) at the label-recommended dose rate (n = 158.) On day 330, effectiveness was evaluated in each dog using antigen and microfilarial (modified Knott’s) testing to assess the establishment of any patent adult heartworm infections. Results All dogs treated with the IP combination product and the CP tested negative (100% prevention) for heartworm infection on day 330. The IP combination product tablets containing milbemycin oxime and lotilaner were well tolerated based on the safety assessments in all treated dogs. Conclusions This multi-site clinical study using client-owned dogs demonstrated that monthly use of flavored, chewable tablets containing a combination of milbemycin oxime and lotilaner administered orally under end use conditions is safe for dogs. None of the enrolled dogs developed heartworm infections. Eleven consecutive monthly treatments of the IP provided 100% prevention of heartworm disease caused by D. immitis. Graphic Abstract

Afinação justa, crivos e (as)simetrias: estratégias composicionais com implementação em OpenMusic

Nesta pesquisa apresentaremos formas de organização de alturas da Afinação Justa através dos crivos de Iannis Xenakis. Nos concentraremos na Afinação Justa de Harry Partch com a Tonalidade-Diamante, no sistema de Afinação utilizado por Ben Johnston nos quartetos de cordas no. 2 e no. 3, no Moment of Symmetry de Erv Wilson, e por fim no Combination Product-Set também de Erv Wilson. Após a apresentação destes sistemas faremos considerações sobre o uso dos crivos para o controle da Afinação Justa dentro de nosso contexto composicional. Após essa parte teórica, apresentaremos as bibliotecas OM-JI e OM-Sieves, desenvolvidas como parte desta pesquisa para facilitar a incorporação da Afinação Justa e dos crivos no ambiente do OpenMusic/OM-Sharp, finalizando com processos composicionais criados a partir dos crivos e das Afinações Justas dentro da obra Arabesque | 19 11 97.