BCX-4161, a Small Molecule and Orally Bioavailable Plasma Kallikrein Inhibitor for the Treatment of Hereditary Angioedema

2013 ◽  
Vol 131 (2) ◽  
pp. AB211 ◽  
Author(s):  
Shanta Bantia ◽  
Jianwen Zhang ◽  
Ramanda Wilson ◽  
Cynthia D. Parker ◽  
Debra Kellogg ◽  
...  
Keyword(s):  
Small Molecule ◽  
Hereditary Angioedema ◽  
Plasma Kallikrein ◽  
Kallikrein Inhibitor ◽  
Orally Bioavailable

Berotralstat (BCX7353): Structure-Guided Design of a Potent, Selective, and Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE)

2021 ◽  
Vol 64 (17) ◽  
pp. 12453-12468
Author(s):  
Pravin L Kotian ◽  
Minwan Wu ◽  
Satish Vadlakonda ◽  
Venkat Chintareddy ◽  
Pengcheng Lu ◽  
...  
Keyword(s):  
Hereditary Angioedema ◽  
Plasma Kallikrein ◽  
Kallikrein Inhibitor

scholarly journals Preclinical Characterization of BCX7353, an Oral Plasma Kallikrein Inhibitor, for the Treatment of Hereditary Angioedema (HAE)

2017 ◽  
Vol 139 (2) ◽  
pp. AB230 ◽  
Author(s):  
Xilin Chen ◽  
Pravin Kotian ◽  
Ramanda Wilson ◽  
Cynthia D. Parker ◽  
Y.S. Babu
Keyword(s):  
Hereditary Angioedema ◽  
Plasma Kallikrein ◽  
Kallikrein Inhibitor
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