Oral Plasma Kallikrein Inhibitor BCX7353 is Safe and Effective as an On-Demand Treatment of Angioedema Attacks in Hereditary Angioedema (HAE) Patients: Results of the ZENITH-1 Trial

Hilary Longhurst; Dumitru Moldovan; Anette Bygum; Marco Cicardi; Aarnoud Huissoon; Emel Aygoren-Pursun; Vesna Grivcheva-Panovska; David Hagin; Urs Steiner; Marcin Stobiecki; Werner Aberer; Claire Bethune; Saul N. Faust; Sorena Kiani; David Launay; Marcus Maurer; William Rae; Avner Reshef; Melanie T. Cornpropst; Sylvia M. Dobo; Sharon VanDyke; Sharon Murray; Phillip J. Collis; William P. Sheridan; Henriette Farkas

doi:10.1016/j.jaci.2018.12.112

Oral Plasma Kallikrein Inhibitor BCX7353 is Safe and Effective as an On-Demand Treatment of Angioedema Attacks in Hereditary Angioedema (HAE) Patients: Results of the ZENITH-1 Trial

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2018.12.112 ◽

2019 ◽

Vol 143 (2) ◽

pp. AB36 ◽

Cited By ~ 1

Author(s):

Hilary Longhurst ◽

Dumitru Moldovan ◽

Anette Bygum ◽

Marco Cicardi ◽

Aarnoud Huissoon ◽

...

Keyword(s):

Hereditary Angioedema ◽

Plasma Kallikrein ◽

Kallikrein Inhibitor ◽

On Demand

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KVD900 as a Single Dose, Rapid, Oral Plasma Kallikrein Inhibitor for the On-Demand Treatment of Hereditary Angioedema Attacks: Pharmacokinetic and Pharmacodynamic results from a Phase 1 Single Ascending Dose Study

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2018.12.118 ◽

2019 ◽

Vol 143 (2) ◽

pp. AB39 ◽

Cited By ~ 1

Author(s):

Sally L. Hampton ◽

Gian Marco De Donatis ◽

Nivetha I. Murugesan ◽

Louise J. Rushbrooke ◽

Lily Li ◽

...

Keyword(s):

Single Dose ◽

Hereditary Angioedema ◽

Phase 1 ◽

Plasma Kallikrein ◽

Kallikrein Inhibitor ◽

On Demand ◽

Dose Study ◽

Single Ascending Dose Study

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Berotralstat (BCX7353): Structure-Guided Design of a Potent, Selective, and Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE)

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c00511 ◽

2021 ◽

Vol 64 (17) ◽

pp. 12453-12468

Author(s):

Pravin L Kotian ◽

Minwan Wu ◽

Satish Vadlakonda ◽

Venkat Chintareddy ◽

Pengcheng Lu ◽

...

Keyword(s):

Hereditary Angioedema ◽

Plasma Kallikrein ◽

Kallikrein Inhibitor

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Ecallantide: A plasma kallikrein inhibitor for the treatment of acute attacks of hereditary angioedema

Drugs of Today ◽

10.1358/dot.2010.46.8.1507205 ◽

2010 ◽

Vol 46 (8) ◽

pp. 547 ◽

Cited By ~ 8

Author(s):

L.E. Stolz ◽

P.T. Horn

Keyword(s):

Hereditary Angioedema ◽

Plasma Kallikrein ◽

Kallikrein Inhibitor ◽

Acute Attacks

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Preclinical Characterization of BCX7353, an Oral Plasma Kallikrein Inhibitor, for the Treatment of Hereditary Angioedema (HAE)

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2016.12.741 ◽

2017 ◽

Vol 139 (2) ◽

pp. AB230 ◽

Cited By ~ 2

Author(s):

Xilin Chen ◽

Pravin Kotian ◽

Ramanda Wilson ◽

Cynthia D. Parker ◽

Y.S. Babu

Keyword(s):

Hereditary Angioedema ◽

Plasma Kallikrein ◽

Kallikrein Inhibitor

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Use of recombinant plasma kallikrein inhibitor in hereditary angioedema: A case report and review of the management of the disorder

Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.joms.2004.07.010 ◽

2004 ◽

Vol 62 (12) ◽

pp. 1553-1556 ◽

Cited By ~ 7

Author(s):

Michael D. Turner ◽

Amina Oughourli ◽

Kevin Heaney ◽

Thomas Selvaggi

Keyword(s):

Case Report ◽

Hereditary Angioedema ◽

Plasma Kallikrein ◽

Kallikrein Inhibitor

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Resolution of bowel obstruction in a patient with hereditary angioedema treated with DX-88 (Ecallantide1), a potent human plasma kallikrein inhibitor: A case study

Molecular Immunology ◽

10.1016/j.molimm.2006.07.035 ◽

2007 ◽

Vol 44 (1-3) ◽

pp. 160

Author(s):

Marco Cicardi ◽

Lorenza C. Zingale ◽

Andrea Zanichelli

Keyword(s):

Human Plasma ◽

Bowel Obstruction ◽

Hereditary Angioedema ◽

Plasma Kallikrein ◽

Kallikrein Inhibitor

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A patient with hereditary angioedema who experienced anaphylaxis in response to C1 esterase inhibitor is successfully treated with DX-88 (Ecallantide1), a potent human plasma kallikrein inhibitor: A case study

Molecular Immunology ◽

10.1016/j.molimm.2006.07.036 ◽

2007 ◽

Vol 44 (1-3) ◽

pp. 160-161

Author(s):

Marco Cicardi ◽

Lorenza C. Zingale ◽

Andrea Zanichelli

Keyword(s):

Human Plasma ◽

Hereditary Angioedema ◽

Plasma Kallikrein ◽

Kallikrein Inhibitor ◽

C1 Esterase Inhibitor ◽

Esterase Inhibitor

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Ecallantide (DX-88), a plasma kallikrein inhibitor for the treatment of hereditary angioedema and the prevention of blood loss in on-pump cardiothoracic surgery

Expert Opinion on Biological Therapy ◽

10.1517/14712598.8.8.1187 ◽

2008 ◽

Vol 8 (8) ◽

pp. 1187-1199 ◽

Cited By ~ 50

Author(s):

Andreas Lehmann

Keyword(s):

Blood Loss ◽

Hereditary Angioedema ◽

Cardiothoracic Surgery ◽

Plasma Kallikrein ◽

Kallikrein Inhibitor

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Results of a 2-Stage, Phase 3 Pivotal Trial, EDEMA3®: A Study of Subcutaneous DX-88 (Ecallantide), a Plasma Kallikrein Inhibitor, in Patients with Hereditary Angioedema (HAE)

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2007.12.1190 ◽

2008 ◽

Vol 121 (2) ◽

pp. S231-S231 ◽

Cited By ~ 7

Author(s):

R LEVY ◽

D MCNEIL ◽

H LI ◽

F HSU ◽

P HORN ◽

...

Keyword(s):

Hereditary Angioedema ◽

Plasma Kallikrein ◽

Pivotal Trial ◽

Phase 3 ◽

Kallikrein Inhibitor

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BCX-4161, a Small Molecule and Orally Bioavailable Plasma Kallikrein Inhibitor for the Treatment of Hereditary Angioedema

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2012.12.1425 ◽

2013 ◽

Vol 131 (2) ◽

pp. AB211 ◽

Cited By ~ 5

Author(s):

Shanta Bantia ◽

Jianwen Zhang ◽

Ramanda Wilson ◽

Cynthia D. Parker ◽

Debra Kellogg ◽

...

Keyword(s):

Small Molecule ◽

Hereditary Angioedema ◽

Plasma Kallikrein ◽

Kallikrein Inhibitor ◽

Orally Bioavailable

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