scholarly journals Rapid Nasal Symptom Onset of Action and Ocular Symptom Relief With Olopatadine/Mometasone Combination Nasal Spray in Patients with Seasonal Allergic Rhinitis: A Pooled Analysis

2019 ◽  
Vol 143 (2) ◽  
pp. AB62 ◽  
Author(s):  
Bruce Prenner ◽  
Frank Hampel ◽  
Nelumka Fernando ◽  
Cynthia F. Caracta ◽  
Sudeesh K. Tantry
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Spray ◽  
Symptom Onset ◽  
Seasonal Allergic Rhinitis ◽  
Symptom Relief ◽  
Pooled Analysis ◽  
Nasal Symptom ◽  
Ocular Symptom ◽  
Onset Of Action

Onset of Action of Azelastine Nasal Spray Compared with Mometasone Nasal Spray and Placebo in Subjects with Seasonal Allergic Rhinitis Evaluated in an Environmental Exposure Chamber

2007 ◽  
Vol 21 (4) ◽  
pp. 499-503 ◽  
Author(s):  
Piyush Patel ◽  
Carrie D'Andrea ◽  
Harry J. Sacks
Keyword(s):  
Allergic Rhinitis ◽  
Environmental Exposure ◽  
Nasal Spray ◽  
Seasonal Allergic Rhinitis ◽  
Allergen Challenge ◽  
Nasal Symptom ◽  
Exposure Chamber ◽  
Onset Of Action ◽  
Environmental Exposure Chamber ◽  
Time Point

Background The objective of this study was to determine the onset of action of azelastine hydrochloride nasal spray compared with placebo and an intranasal steroid, mometasone furoate, in subjects with seasonal allergic rhinitis (SAR). Methods Subjects with a history of SAR and symptomatic while exposed to ragweed pollen in an environmental exposure chamber (EEC) were randomized to azelastine nasal spray (n = 150), mometasone nasal spray (n = 150), or placebo (n = 150) and recorded total nasal symptom scores (TNSS), consisting of sneezing, nasal pruritus, rhinorrhea, and congestion, during an 8-hour study period. Results Azelastine nasal spray showed a statistically significant improvement in the TNSS at 15 minutes compared with placebo. The effect was durable at each time point during the 8-hour study. Azelastine nasal spray also was significantly more effective than mometasone at each time point. Conclusion Azelastine nasal spray has a rapid (15 minute) onset of action. Azelastine nasal spray was superior to both placebo and mometasone nasal spray in reducing nasal symptoms of SAR occurring within 8 hours after an allergen challenge.

Onset of action of mometasone furoate nasal spray (NASONEX® ) in seasonal allergic rhinitis

Allergy ◽  
1999 ◽  
Vol 54 (1) ◽  
pp. 64-69 ◽  
Author(s):  
Rb Berkowitz ◽  
Di Bernstein ◽  
C LaForce ◽  
Aj Pedinoff ◽  
Ar Rooklin ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Spray ◽  
Seasonal Allergic Rhinitis ◽  
Mometasone Furoate ◽  
Onset Of Action
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