IC-P1-037: Functional magnetic resonance imaging activation patterns in cognitively normal elderly, amnestic, and non-amnestic Mild Cognitive Impairment during a recognition memory task

2008 ◽  
Vol 4 ◽  
pp. T23-T24 ◽  
Author(s):  
Mary M. Machulda ◽  
Matthew L. Senjem ◽  
Glenn E. Smith ◽  
Robert J. Ivnik ◽  
Bradley F. Boeve ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Magnetic Resonance ◽  
Memory Task ◽  
Amnestic Mild Cognitive Impairment ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Activation Patterns ◽  
Cognitively Normal

scholarly journals Event-Related Functional Magnetic Resonance Imaging Changes during Relational Retrieval in Normal Aging and Amnestic Mild Cognitive Impairment

2012 ◽  
Vol 18 (5) ◽  
pp. 886-897 ◽  
Author(s):  
Kelly S. Giovanello ◽  
Felipe De Brigard ◽  
Jaclyn Hennessey Ford ◽  
Daniel I. Kaufer ◽  
James R. Burke ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance Imaging ◽  
Amnestic Mild Cognitive Impairment ◽  
Relational Memory ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Amci Group

AbstractThe earliest cognitive deficits observed in amnestic mild cognitive impairment (aMCI) appear to center on memory tasks that require relational memory (RM), the ability to link or integrate unrelated pieces of information. RM impairments in aMCI likely reflect neural changes in the medial temporal lobe (MTL) and posterior parietal cortex (PPC). We tested the hypothesis that individuals with aMCI, as compared to cognitively normal (CN) controls, would recruit neural regions outside of the MTL and PPC to support relational memory. To this end, we directly compared the neural underpinnings of successful relational retrieval in aMCI and CN groups, using event-related functional magnetic resonance imaging (fMRI), holding constant the stimuli and encoding task. The fMRI data showed that the CN, compared to the aMCI, group activated left precuneus, left angular gyrus, right posterior cingulate, and right parahippocampal cortex during relational retrieval, while the aMCI group, relative to the CN group, activated superior temporal gyrus and supramarginal gyrus for this comparison. Such findings indicate an early shift in the functional neural architecture of relational retrieval in aMCI, and may prove useful in future studies aimed at capitalizing on functionally intact neural regions as targets for treatment and slowing of the disease course. (JINS, 2012, 18, 1–12)

scholarly journals Neural Correlates of Mild Behavioral Impairment: A Functional Brain Connectivity Study Using Resting-State Functional Magnetic Resonance Imaging

2021 ◽  
pp. 1-11
Author(s):  
Teruyuki Matsuoka ◽  
Daisuke Ueno ◽  
Zahinoor Ismail ◽  
Ellen Rubinstein ◽  
Hiroyuki Uchida ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cognitive Impairment ◽  
Magnetic Resonance ◽  
Resting State ◽  
Neural Correlates ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Behavioral Impairment ◽  
Cognitively Normal ◽  
Affective Dysregulation

Background: Mild behavioral impairment (MBI) is associated with accelerated cognitive decline and greater risk of dementia. However, the neural correlates of MBI have not been completely elucidated. Objective: The study aimed to investigate the correlation between cognitively normal participants and participants with amnestic mild cognitive impairment (aMCI) using resting-state functional magnetic resonance imaging. Methods: The study included 30 cognitively normal participants and 13 participants with aMCI (20 men and 23 women; mean age, 76.9 years). The MBI was assessed using the MBI checklist (MBI-C). Region of interest (ROI)-to-ROI analysis was performed to examine the correlation between MBI-C scores and functional connectivity (FC) of the default mode network, salience network, and frontoparietal control network (FPCN). Age, Mini-Mental State Examination score, sex, and education were used as covariates. A p-value of 0.05, with false discovery rate correction, was considered significant. Results: A negative correlation was observed between the MBI-C total score and FC of the left posterior parietal cortex with the right middle frontal gyrus. A similar result was obtained for the MBI-C affective dysregulation domain score. Conclusion: FPCN dysfunction was detected as a neural correlate of MBI, especially in the affective dysregulation domain. This dysfunction may be associated with cognitive impairment in MBI and conversion of MBI to dementia; however, further longitudinal data are needed to examine this relationship.

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