Challenges of Monitoring Essential Fatty Acid Deficiency in Home Parenteral Nutrition Patients Intolerant to Intravenous Lipid Emulsions: A Comprehensive Case Study

2019 ◽  
Vol 119 (9) ◽  
pp. A11
Author(s):  
P. Verma ◽  
K. Roberts ◽  
M. Nahikian-Nelms ◽  
H. Estes Doetsch ◽  
P. Hart
Keyword(s):  
Fatty Acid ◽  
Parenteral Nutrition ◽  
Essential Fatty Acid ◽  
Essential Fatty Acid Deficiency ◽  
Home Parenteral Nutrition ◽  
Lipid Emulsions ◽  
Acid Deficiency ◽  
Fatty Acid Deficiency

scholarly journals A Clinical Evaluation of Safflower Oil Emulsion in Total Parenteral Nutrition

1982 ◽  
Vol 10 (3) ◽  
pp. 258-264 ◽  
Author(s):  
D. G. Tabrett ◽  
G. D. Phillips
Keyword(s):  
Fatty Acid ◽  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Essential Fatty Acid ◽  
Essential Fatty Acid Deficiency ◽  
Serum Triglyceride ◽  
Safflower Oil ◽  
Oil Emulsion ◽  
Acid Deficiency ◽  
Fatty Acid Deficiency

A new intravenous safflower oil emulsion (Liposyn, Abbott) was administered to 23 patients receiving total parenteral nutrition. In a prospective clinical trial, 500 ml of the 10% emulsion was administered each day for a minimum of 10 days. Plasma fatty acid estimations showed a rise in linoleic acid in 22 patients, and a fall in triene/tetraene ratio (a guide to the presence of essential fatty acid deficiency), in 17 patients within four days of commencement of the infusion. Administration of Liposyn prevented the development of biochemical evidence of essential fatty acid deficiency. There were no clinical side effects attributable to the emulsion. Elevation of serum triglyceride and liver enzyme concentrations occurred in some patients.

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