Transdermal delivery of insulin across human skin in vitro with 3D printed hollow microneedles

2021 ◽  
pp. 102891
Author(s):  
Iakovos Xenikakis ◽  
Konstantinos Tsongas ◽  
Emmanouil K. Tzimtzimis ◽  
Orestis Katsamenis ◽  
Efterpi Demiri ◽  
...  
Keyword(s):  
Human Skin ◽  
Transdermal Delivery ◽  
3D Printed ◽  
Hollow Microneedles

Fabrication and finite element analysis of stereolithographic 3D printed microneedles for transdermal delivery of model dyes across human skin in vitro

2019 ◽  
Vol 137 ◽  
pp. 104976 ◽  
Author(s):  
Iakovos Xenikakis ◽  
Manolis Tzimtzimis ◽  
Konstantinos Tsongas ◽  
Dimitrios Andreadis ◽  
Euterpi Demiri ◽  
...  
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Human Skin ◽  
Transdermal Delivery ◽  
Element Analysis ◽  
3D Printed

scholarly journals Expression of drug transporters in the human skin: comparison in different species and models and its implication for drug development

ADMET & DMPK ◽  
2017 ◽  
Vol 5 (2) ◽  
pp. 75 ◽  
Author(s):  
Hanan Osman-Ponchet ◽  
Alexandre Gaborit ◽  
Jean-Michel Linget ◽  
Claire E. Wilson
Keyword(s):  
Human Skin ◽  
Drug Absorption ◽  
Transdermal Delivery ◽  
Drug Transporters ◽  
Drug Distribution ◽  
Skin Surface ◽  
Pharmacological Intervention ◽  
Novel Targets

<p class="ADMETabstracttext">It is clear that many drug transporters (both ABCs and SLCs) are present in the human skin. Different in vitro skin models can be used to investigate the role of drug transporters in the skin despite quantitative differences in expression profile across species. P-gp was shown to have an important influence on transdermal drug absorption in the skin and to function in “absorptive” transport, carrying substrate drugs from the skin surface to the dermis. This observation might be used to modulate drug distribution inside the skin. If drugs can be retained in the epidermis compartment by inhibition of the transporters, such property of the drug would be beneficial for treatment of dermatological diseases. Therefore, it might be feasible to control transdermal delivery of drugs to specific locations in the skin, by modulating the function of the transporters in the skin. We are at the dawn of an exciting period where drug transporters might be novel targets for improvement of drug delivery to the skin and for pharmacological intervention.</p>

In Vitro Transdermal Delivery of a Melanotropic Peptide Through Human Skin

1990 ◽  
Vol 94 (4) ◽  
pp. 432-435 ◽  
Author(s):  
Brenda V Dawson ◽  
Mac E Hadley ◽  
Norman Levine ◽  
Kristie L Kreutzfeld ◽  
Scott Don ◽  
...  
Keyword(s):  
Human Skin ◽  
Transdermal Delivery

3D-printed chitosan-based scaffolds: An in vitro study of human skin cell growth and an in-vivo wound healing evaluation in experimental diabetes in rats

2018 ◽  
Vol 199 ◽  
pp. 593-602 ◽  
Author(s):  
Claudio Intini ◽  
Lisa Elviri ◽  
Jaydee Cabral ◽  
Sonya Mros ◽  
Carlo Bergonzi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cell Growth ◽  
Human Skin ◽  
Experimental Diabetes ◽  
In Vitro Study ◽  
Vitro Study ◽  
Skin Cell ◽  
3D Printed

Transdermal Delivery of Naltrexone and its Active Metabolite 6-β-Naltrexol in Human Skin in Vitro and Guinea Pigs in Vivo

2005 ◽  
Vol 94 (9) ◽  
pp. 1965-1975 ◽  
Author(s):  
Kalpana S. Paudel ◽  
Buchi N. Nalluri ◽  
Dana C. Hammell ◽  
Satyanarayana Valiveti ◽  
Paul Kiptoo ◽  
...  
Keyword(s):  
Human Skin ◽  
Transdermal Delivery ◽  
Guinea Pigs ◽  
Active Metabolite

Effect of Lipophilicity on Microneedle-Mediated Iontophoretic Transdermal Delivery Across Human Skin In Vitro

2013 ◽  
Vol 102 (10) ◽  
pp. 3784-3791 ◽  
Author(s):  
Kasturi R. Pawar ◽  
Forrest Smith ◽  
Chandra Sekhar Kolli ◽  
R. Jayachandra Babu
Keyword(s):  
Human Skin ◽  
Transdermal Delivery

3D Printed Hollow Microneedles Array using Stereolithography for Efficient Transdermal Delivery of Rifampicin

2021 ◽  
pp. 120815
Author(s):  
Vivek Yadav ◽  
Peeyush Kumar Sharma ◽  
Upadhyayula Suryanarayana Murty ◽  
Narayan H. Mohan ◽  
Rajendran Thomas ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
3D Printed ◽  
Hollow Microneedles
Sign in / Sign up

Export Citation Format

Share Document