The long-term determinants of female HIV infection in Africa: The slave trade, polygyny, and sexual behavior

The small Slave Coast between the river Volta and Lagos, and especially its central part around Ouidah, was the epicentre of the slave trade in West Africa. But it was also an inhospitable, surf-ridden coastline, subject to crashing breakers and devoid of permanent human settlement. Nor was it easily accessible from the interior due to a lagoon which ran parallel to the coast. The local inhabitants were not only sheltered against incursions from the sea, but were also locked off from it. Yet, paradoxically, this small coastline witnessed a thriving long-term commercial relationship between Europeans and Africans, based on the trans-Atlantic slave trade. How did it come about? How was it all organized? Dahomey is usually cited as the Slave Coast's archetypical slave raiding and slave trading polity. An originally inland realm, it was a latecomer to the slave trade, and simply incorporated a pre-existing system by dint of military prowess, which ultimately was to prove radically counterproductive. Dahomey, which never controlled more than half of the region we call the Slave Coast, represented an anomaly in the local setting, an anomaly the author seeks to define and to explain.

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Unmapped exome reads implicate a role for Anelloviridae in childhood HIV-1 long-term non-progression

npj Genomic Medicine ◽

10.1038/s41525-021-00185-w ◽

2021 ◽

Vol 6 (1) ◽

Author(s):

Savannah Mwesigwa ◽

◽

Lesedi Williams ◽

Gaone Retshabile ◽

Eric Katagirya ◽

...

Keyword(s):

Hiv Infection ◽

Diversity Index ◽

Strong Association ◽

Community Diversity ◽

Added Value ◽

Sequencing Platform ◽

Public Health Burden ◽

Survival Status ◽

Significant Public Health

AbstractHuman immunodeficiency virus (HIV) infection remains a significant public health burden globally. The role of viral co-infection in the rate of progression of HIV infection has been suggested but not empirically tested, particularly among children. We extracted and classified 42 viral species from whole-exome sequencing (WES) data of 813 HIV-infected children in Botswana and Uganda categorised as either long-term non-progressors (LTNPs) or rapid progressors (RPs). The Ugandan participants had a higher viral community diversity index compared to Batswana (p = 4.6 × 10−13), and viral sequences were more frequently detected among LTNPs than RPs (24% vs 16%; p = 0.008; OR, 1.9; 95% CI, 1.6–2.3), with Anelloviridae showing strong association with LTNP status (p = 3 × 10−4; q = 0.004, OR, 3.99; 95% CI, 1.74–10.25). This trend was still evident when stratified by country, sex, and sequencing platform, and after a logistic regression analysis adjusting for age, sex, country, and the sequencing platform (p = 0.02; q = 0.03; OR, 7.3; 95% CI, 1.6–40.5). Torque teno virus (TTV), which made up 95% of the Anelloviridae reads, has been associated with reduced immune activation. We identify an association between viral co-infection and prolonged AIDs-free survival status that may have utility as a biomarker of LTNP and could provide mechanistic insights to HIV progression in children, demonstrating the added value of interrogating off-target WES reads in cohort studies.

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