scholarly journals Unmapped exome reads implicate a role for Anelloviridae in childhood HIV-1 long-term non-progression

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Savannah Mwesigwa ◽  
◽  
Lesedi Williams ◽  
Gaone Retshabile ◽  
Eric Katagirya ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Diversity Index ◽  
Strong Association ◽  
Community Diversity ◽  
Added Value ◽  
Sequencing Platform ◽  
Public Health Burden ◽  
Survival Status ◽  
Significant Public Health

AbstractHuman immunodeficiency virus (HIV) infection remains a significant public health burden globally. The role of viral co-infection in the rate of progression of HIV infection has been suggested but not empirically tested, particularly among children. We extracted and classified 42 viral species from whole-exome sequencing (WES) data of 813 HIV-infected children in Botswana and Uganda categorised as either long-term non-progressors (LTNPs) or rapid progressors (RPs). The Ugandan participants had a higher viral community diversity index compared to Batswana (p = 4.6 × 10−13), and viral sequences were more frequently detected among LTNPs than RPs (24% vs 16%; p = 0.008; OR, 1.9; 95% CI, 1.6–2.3), with Anelloviridae showing strong association with LTNP status (p = 3 × 10−4; q = 0.004, OR, 3.99; 95% CI, 1.74–10.25). This trend was still evident when stratified by country, sex, and sequencing platform, and after a logistic regression analysis adjusting for age, sex, country, and the sequencing platform (p = 0.02; q = 0.03; OR, 7.3; 95% CI, 1.6–40.5). Torque teno virus (TTV), which made up 95% of the Anelloviridae reads, has been associated with reduced immune activation. We identify an association between viral co-infection and prolonged AIDs-free survival status that may have utility as a biomarker of LTNP and could provide mechanistic insights to HIV progression in children, demonstrating the added value of interrogating off-target WES reads in cohort studies.

Myelodysplastic features in patients with long-term HIV infection and haemophilia

Haemophilia ◽  
2001 ◽  
Vol 7 (1) ◽  
pp. 47-52 ◽  
Author(s):  
O. Katsarou ◽  
E. Terpos ◽  
E. Patsouris ◽  
P. Peristeris ◽  
N. Viniou ◽  
...  
Keyword(s):  
Hiv Infection

scholarly journals Association between multimorbidity patterns and disability among older people covered by long-term care insurance in Shanghai, China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zijing Wang ◽  
Wenjia Peng ◽  
Mengying Li ◽  
Xinghui Li ◽  
Tingting Yang ◽  
...  
Keyword(s):  
Older People ◽  
Functional Disability ◽  
Long Term Care ◽  
Strong Association ◽  
Binary Logistic Regression ◽  
Term Care ◽  
Logistic Regression Models ◽  
Disease Pattern ◽  
Long Term Care Insurance

Abstract Background Functional disability and multimorbidity are common among older people. However, little is known about the relationship between functional disability and different multimorbidity combinations. We aimed to identify multimorbidity patterns and explore the associations between these patterns and functional disability. Methods We investigated a multi-stage random sample of 1871 participants aged ≥60 years and covered by long-term care insurance in Shanghai, China. Multimorbidity was defined as the simultaneous presence of two or more chronic diseases in an individual. Participants completed scales to assess basic and instrumental activities of daily living (BADL and IADL, respectively). Multimorbidity patterns were identified via exploratory factor analysis. Binary logistic regression models were used to determine adjusted associations between functional disability and number and patterns of multimorbidity. Results Multimorbidity was present in 74.3% of participants. The prevalence of BADL disability was 50.7% and that of IADL disability was 90.7%. There was a strong association between multimorbidity and disability. We identified three multimorbidity patterns: musculoskeletal, cardio-metabolic, and mental-degenerative diseases. The cardio-metabolic disease pattern was associated with both BADL (OR 1.28, 95%CI 1.16–1.41) and IADL (OR 1.41, 95%CI 1.19–1.68) disability. The mental-degenerative disease pattern was associated with BADL disability (OR 1.55, 95%CI 1.40–1.72). Conclusions Multimorbidity and functional disability are highly prevalent among older people covered by long-term care insurance in Shanghai, and distinct multimorbidity patterns are differentially associated with functional disability. Appropriate long-term healthcare and prevention strategies for older people may help reduce multimorbidity, maintain functional ability, and improve health-related quality of life.

scholarly journals The Symbiotic Mutualism between Co-Creation and Entrepreneurship

2021 ◽  
Vol 13 (11) ◽  
pp. 6285
Author(s):  
Sandra Misiak-Kwit ◽  
Małgorzata Wiścicka-Fernando ◽  
Kelaniyage Shihan Dilruk Fernando
Keyword(s):  
Pilot Study ◽  
Small Sample Size ◽  
Strong Association ◽  
Sampling Technique ◽  
Small Sample ◽  
Entrepreneurial Intentions ◽  
Added Value ◽  
Primary Data ◽  
Exploratory Research ◽  
Symbiotic Mutualism

In this manuscript, the authors aim to explore firstly the association between entrepreneurial mindset and co-creation experience, secondly the association between co-creation experience and entrepreneurial intentions, and thirdly the association between entrepreneurial mindset and entrepreneurial intentions within the sustainability context. In this paper, the authors present the results of the pilot study. Primary data were collected from 500 university students from China, Georgia, Poland, Romania, and Sri Lanka by using a convenient sampling technique, and a literature review was the primary method of the concept development. The authors selected the above-mentioned countries to collect primary data by using a convenient sampling technique based on accessibility; they also visited all analysed countries in order to conduct the pilot survey personally. Descriptive statistics and the Spearman’s rank correlation coefficient were applied as primary statistical methods. The findings reveal that there is a very strong association between co-creation experience and entrepreneurial intentions, a very weak negative association between entrepreneurial mindset and co-creation experience, and, surprisingly, a weak association between entrepreneurial mindset and entrepreneurial intentions. The added value of the conducted pilot research involves filling in a gap regarding the relationship between experience and the subjective norm. In the presented pilot research, co-creation experience was compared with not only entrepreneurial mindset but with entrepreneurial intentions as well. An additional value of this exploratory research is compiling an international comparison. The main contribution of this pilot study is examining the symbiotic mutualism between co-creation and entrepreneurship. Among many platforms of associations, the following can be differentiated: creativity, innovativeness, openness, engagement, awareness, motivation, trust (level of social capital), and recognizing the significance of social and sustainable development objectives. Due to the small sample size, the results cannot be generalised. Results refer only to the respondents. However, the findings of the pilot study are the basis for further research studies on symbiotic mutualism between entrepreneurship and co-creation.

scholarly journals Global Health Impacts of Dust Storms: A Systematic Review

2021 ◽  
Vol 15 ◽  
pp. 117863022110183
Author(s):  
Hamidreza Aghababaeian ◽  
Abbas Ostadtaghizadeh ◽  
Ali Ardalan ◽  
Ali Asgary ◽  
Mehry Akbary ◽  
...  
Keyword(s):  
Public Health ◽  
Systematic Review ◽  
Respiratory Health ◽  
Dust Storms ◽  
Health Impacts ◽  
Public Health Issue ◽  
Emergency Medical Dispatch ◽  
Significant Public Health ◽  
English Articles

Background: Dust storms and their impacts on health are becoming a major public health issue. The current study examines the health impacts of dust storms around the world to provide an overview of this issue. Method: In this systematic review, 140 relevant and authoritative English articles on the impacts of dust storms on health (up to September 2019) were identified and extracted from 28 968 articles using valid keywords from various databases (PubMed, WOS, EMBASE, and Scopus) and multiple screening steps. Selected papers were then qualitatively examined and evaluated. Evaluation results were summarized using an Extraction Table. Results: The results of the study are divided into two parts: short and long-term impacts of dust storms. Short-term impacts include mortality, visitation, emergency medical dispatch, hospitalization, increased symptoms, and decreased pulmonary function. Long-term impacts include pregnancy, cognitive difficulties, and birth problems. Additionally, this study shows that dust storms have devastating impacts on health, affecting cardiovascular and respiratory health in particular. Conclusion: The findings of this study show that dust storms have significant public health impacts. More attention should be paid to these natural hazards to prepare for, respond to, and mitigate these hazardous events to reduce their negative health impacts. Registration: PROSPERO registration number CRD42018093325

scholarly journals Antioxidant Therapy in Inflammatory Bowel Diseases

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 412
Author(s):  
Katarzyna Dziąbowska-Grabias ◽  
Małgorzata Sztanke ◽  
Przemysław Zając ◽  
Michał Celejewski ◽  
Katarzyna Kurek ◽  
...  
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Nitrosative Stress ◽  
Treatment Options ◽  
Chemical Compounds ◽  
Continuous Increase ◽  
Public Health Burden ◽  
Bowel Diseases ◽  
Significant Public Health ◽  
Inflammatory Bowel

Inflammatory bowel diseases (IBD) are a group of chronic, incurable diseases of the digestive tract, the etiology of which remains unclear to this day. IBD result in significant repercussions on the quality of patients’ life. There is a continuous increase in the incidence and prevalence of IBD worldwide, and it is becoming a significant public health burden. Pharmaceuticals commonly used in IBD management, for example, mesalamine, sulfasalazine, corticosteroids, and others, expose patients to diverse, potentially detrimental side effects and frequently do not provide sufficient disease control. The chronic inflammation underlies the etiology of IBD and closely associates with oxidative/nitrosative stress and a vast generation of reactive oxygen/nitrogen species. Relative to this, several substances with antioxidant and anti-inflammatory properties are now intensively researched as possible adjunctive or independent treatment options in IBD. Representatives of several different groups, including natural and chemical compounds will be characterized in this dissertation.

scholarly journals Altered Immunity and Microbial Dysbiosis in Aged Individuals With Long-Term Controlled HIV Infection

2019 ◽  
Vol 10 ◽  
Author(s):  
Nicholas Rhoades ◽  
Norma Mendoza ◽  
Allen Jankeel ◽  
Suhas Sureshchandra ◽  
Alexander D. Alvarez ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Microbial Dysbiosis

scholarly journals Techniques for analyses of trends in GRUAN data

2015 ◽  
Vol 8 (4) ◽  
pp. 1673-1684 ◽  
Author(s):  
G. E. Bodeker ◽  
S. Kremser
Keyword(s):  
Measurement Uncertainty ◽  
Trend Analysis ◽  
Global Climate ◽  
Regional Climate ◽  
Added Value ◽  
Least Squares Regression ◽  
Target Uncertainty ◽  
Reference Quality ◽  
Measurement Uncertainties

Abstract. The Global Climate Observing System (GCOS) Reference Upper Air Network (GRUAN) provides reference quality RS92 radiosonde measurements of temperature, pressure and humidity. A key attribute of reference quality measurements, and hence GRUAN data, is that each datum has a well characterized and traceable estimate of the measurement uncertainty. The long-term homogeneity of the measurement records, and their well characterized uncertainties, make these data suitable for reliably detecting changes in global and regional climate on decadal time scales. Considerable effort is invested in GRUAN operations to (i) describe and analyse all sources of measurement uncertainty to the extent possible, (ii) quantify and synthesize the contribution of each source of uncertainty to the total measurement uncertainty, and (iii) verify that the evaluated net uncertainty is within the required target uncertainty. However, if the climate science community is not sufficiently well informed on how to capitalize on this added value, the significant investment in estimating meaningful measurement uncertainties is largely wasted. This paper presents and discusses the techniques that will need to be employed to reliably quantify long-term trends in GRUAN data records. A pedagogical approach is taken whereby numerical recipes for key parts of the trend analysis process are explored. The paper discusses the construction of linear least squares regression models for trend analysis, boot-strapping approaches to determine uncertainties in trends, dealing with the combined effects of autocorrelation in the data and measurement uncertainties in calculating the uncertainty on trends, best practice for determining seasonality in trends, how to deal with co-linear basis functions, and interpreting derived trends. Synthetic data sets are used to demonstrate these concepts which are then applied to a first analysis of temperature trends in RS92 radiosonde upper air soundings at the GRUAN site at Lindenberg, Germany (52.21° N, 14.12° E).

Specificity and Sensitivity of Hemosiderin-Laden Macrophages in Routine Bronchoalveolar Lavage in Children

2006 ◽  
Vol 130 (11) ◽  
pp. 1684-1686 ◽  
Author(s):  
Zeynep N. Salih ◽  
Afreen Akhter ◽  
Javeed Akhter
Keyword(s):  
Bronchoalveolar Lavage ◽  
Sensitivity And Specificity ◽  
Pediatric Population ◽  
Strong Association ◽  
Clinical Findings ◽  
Clinical Syndrome ◽  
Pulmonary Hemosiderosis ◽  
Specificity And Sensitivity ◽  
Long Term Prognosis

Abstract Context.—The presence of iron or hemosiderin in macrophages obtained in routine bronchoalveolar lavage is considered crucial in the diagnosis of the clinical syndrome of hemosiderosis. However, there do not appear to be any data on the sensitivity and specificity of the finding of hemosiderin-laden macrophages (HLMs) in bronchoalveolar lavage in children. Objective.—To review data from bronchoalveolar lavage studies done in children to correlate the presence of HLMs with pneumonia and hemosiderosis and to determine what proportion of HLMs has the optimal sensitivity and specificity for the diagnosis of hemosiderosis. Design.—One hundred ten bronchoalveolar lavage specimens obtained via flexible bronchoscopy were reviewed retrospectively. The data collected for demographics, indication for the bronchoscopy, diagnosis of pneumonia, anemia, and bronchoscopy and bronchoalveolar lavage findings were compared between patients diagnosed with hemosiderosis and those diagnosed with other diseases. Results.—Six patients were diagnosed with hemosiderosis by clinical findings, lung biopsy, or autopsy. There were no statistical differences in pneumonia (P > .99), anemia (P > .99), or coughing (P = .08) between patients with hemosiderosis and other patients. Hemoptysis was the only symptom that was significantly different between the 2 groups (P = .04). The mean HLM index for patients with hemosiderosis was 56% ± 16.17% and for other patients, 7.5% ± 10.74% (P < .001). A HLM index of 35% gave a sensitivity of 1% and a specificity of .96%. Conclusions.—These results confirm a strong association between HLM index and diagnosis of hemosiderosis in a pediatric population. Availability of this HLM index will result in accurate and timely diagnosis of pulmonary hemosiderosis, which may influence treatment and long-term prognosis.

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