Coupling of sterically hindered aldehyde with fluorinated synthons: Stereoselective synthesis of fluorinated analogues of salinosporamide A

2012 ◽  
Vol 136 ◽  
pp. 12-19 ◽  
Author(s):  
Zeng-Hao Chen ◽  
Bing-Lin Wang ◽  
Andrew J. Kale ◽  
Bradley S. Moore ◽  
Ruo-Wen Wang ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Salinosporamide A ◽  
Sterically Hindered

ChemInform Abstract: Coupling of Sterically Hindered Aldehyde with Fluorinated Synthons: Stereoselective Synthesis of Fluorinated Analogues of Salinosporamide A.

ChemInform ◽  
2012 ◽  
Vol 43 (33) ◽  
pp. no-no
Author(s):  
Zeng-Hao Chen ◽  
Bing-Lin Wang ◽  
Andrew J. Kale ◽  
Bradley S. Moore ◽  
Ruo-Wen Wang ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Salinosporamide A ◽  
Sterically Hindered

Stereoselective synthesis of enones from the reaction of aldehydes with sterically hindered dimethylaluminum enolates

2005 ◽  
Vol 690 (14) ◽  
pp. 3474-3478 ◽  
Author(s):  
Zachary S. Sales ◽  
Roger Nassar ◽  
J. Jacob Morris ◽  
Kenneth W. Henderson
Keyword(s):  
Stereoselective Synthesis ◽  
Sterically Hindered

Stereoselective Synthesis of 3-azabicyclo[3,3,1]Nonan-9α-yl α-(cyclopentyl-1-ene)-α-hydroxy-α-phenylacetate Hydrochloride

2005 ◽  
Vol 2005 (5) ◽  
pp. 322-323 ◽  
Author(s):  
He Liu ◽  
Xiang-Yu Han ◽  
Bo-Hua Zhong ◽  
Ke-Liang Liu
Keyword(s):  
Mandelic Acid ◽  
Phenylacetic Acid ◽  
Stereoselective Synthesis ◽  
Enantiomeric Excess ◽  
Starting Material ◽  
Sterically Hindered ◽  
Acid Esters

The isomers of α-(cyclopentyl-1-ene)-α-hydroxy-α-phenylacetic acid esters derived from 3-azabicyclo[3,3,1]nonan-9α-ol ((R)-1 and (S)-1) were obtained in high enantiomeric excess by effective stereoselective synthesis from the chiral starting material, (S) or (R)-mandelic acid using pivaldehyde as a sterically hindered reagent

N-Isopropylsulfinylimines vs. N-tert-butylsulfinylimines in the stereoselective synthesis of sterically hindered amines: an improved synthesis of enantiopure (R)- and (S)-rimantadine and the trifluoromethylated analogues

2019 ◽  
Vol 17 (46) ◽  
pp. 9854-9858 ◽  
Author(s):  
Nazaret Moreno ◽  
Rocío Recio ◽  
Victoria Valdivia ◽  
Noureddine Khiar ◽  
Inmaculada Fernández
Keyword(s):  
Stereoselective Synthesis ◽  
Sterically Hindered ◽  
Hindered Amines

In contrast to N-tert-butylsulfinylimines, the use of N-isopropylsulfinylimines as starting chiral material allows the stereoselective synthesis of both enantiomers of rimantadine and its trifluoromethylated analogues.

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