Comparison of single-drop microextraction with microvolume pipette extraction directly coupled with capillary electrophoresis for extraction and separation of tricyclic antidepressant drugs

2014 ◽  
Vol 20 (4) ◽  
pp. 2071-2076 ◽  
Author(s):  
Hui-Fen Wu ◽  
Suresh Kumar Kailasa ◽  
Ja-Yi Yan ◽  
Chen-Che Chin ◽  
Hsin-Yi Ku
Keyword(s):  
Capillary Electrophoresis ◽  
Antidepressant Drugs ◽  
Tricyclic Antidepressant ◽  
Single Drop ◽  
Extraction And Separation ◽  
Tricyclic Antidepressant Drugs ◽  
Single Drop Microextraction

Facile and highly efficient three-phase single drop microextraction in-line coupled with capillary electrophoresis

2021 ◽  
pp. 462520
Author(s):  
Sunkyung Jeong ◽  
Joseph E. Valdez ◽  
Natalia Miękus ◽  
Joon Yub Kwon ◽  
Wooyong Kwon ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Single Drop ◽  
Highly Efficient ◽  
Three Phase ◽  
Single Drop Microextraction

Quantitative liquid-chromatographic technique for the simultaneous assay of tricyclic antidepressant drugs in plasma or serum.

1982 ◽  
Vol 28 (3) ◽  
pp. 457-461 ◽  
Author(s):  
P K Sonsalla ◽  
T A Jennison ◽  
B S Finkle
Keyword(s):  
Antidepressant Drugs ◽  
Isoamyl Alcohol ◽  
Solvent System ◽  
Tricyclic Antidepressant ◽  
Chromatographic Technique ◽  
Internal Standards ◽  
Tricyclic Antidepressant Drugs ◽  
Drug Concentrations ◽  
Micrometer Particle ◽  
Liquid Chromatographic

Abstract A quantitative "high-pressure" liquid-chromatographic assay for tricyclic antidepressant drugs in plasma or serum is described in which amitriptyline, nortriptyline, imipramine, desipramine, doxepin, and desmethyldoxepin are separated with a 10-micrometer particle size silica column and a methanol/NH4OH/NH4NO3 solvent system. The drugs and two internal standards are extracted with hexane/isoamyl alcohol, the solvent layer is evaporated at 40 degrees C, and the drugs are detected at 254 nm. Drug concentrations are linear with absorbance from 25 to 1000 micrograms/L; within-assay and between-assay CVs are less than or equal to 10%.

Sign in / Sign up

Export Citation Format

Share Document