MP53-18 EFFICACY OF LOCAL TREATMENT IN PROSTATE CANCER PATIENTS WITH CLINICALLY PELVIC LYMPH NODE-POSITIVE DISEASE AT INITIAL DIAGNOSIS

2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
Thomas Seisen ◽  
Malte W Vetterlein ◽  
Patrick Karabon ◽  
Tarun Jindal ◽  
Akshay Sood ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Local Treatment ◽  
Initial Diagnosis ◽  
Pelvic Lymph Node ◽  
Node Positive ◽  
Node Positive Disease ◽  
Lymph Node Positive

Efficacy of Local Treatment in Prostate Cancer Patients with Clinically Pelvic Lymph Node-positive Disease at Initial Diagnosis

2018 ◽  
Vol 73 (3) ◽  
pp. 452-461 ◽  
Author(s):  
Thomas Seisen ◽  
Malte W. Vetterlein ◽  
Patrick Karabon ◽  
Tarun Jindal ◽  
Akshay Sood ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Local Treatment ◽  
Initial Diagnosis ◽  
Pelvic Lymph Node ◽  
Node Positive ◽  
Node Positive Disease ◽  
Lymph Node Positive

Efficacy of local treatment in patients with prostate cancer with clinically pelvic lymph node-positive disease at initial diagnosis.

2017 ◽  
Vol 35 (6_suppl) ◽  
pp. 164-164 ◽  
Author(s):  
Firas Abdollah ◽  
Thomas Seisen ◽  
Malte Vetterlein ◽  
Patrick Karabon ◽  
Tarun Jindal ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Survival Benefit ◽  
Local Treatment ◽  
Pelvic Lymph Node ◽  
Free Survival ◽  
Node Positive ◽  
Significant Difference ◽  
Lymph Node Positive ◽  
Overall Mortality

164 Background: There is limited evidence supporting the use of local treatment (LT) for prostate cancer (PCa) patients with clinically pelvic lymph node-positive (cN1) disease. Against this backdrop, we sought to examine the efficacy of any form of LT+/-androgen deprivation therapy (ADT) in treating these individuals. Methods: Within the National Cancer Data Base (2004-2012), we identified 2,967 individuals who received LT+/-ADT vs. ADT alone for cN1 PCa. Only radical prostatectomy (RP) and radiation therapy (RT) were considered as definitive LT. Instrumental variable analyses (IVA) were performed using a two-stage residual inclusion approach to compare overall mortality-free survival between patients who were treated with LT+/-ADT vs. ADT alone. The same methodology was used to further compare overall mortality-free survival between patients who were treated with RP+/-ADT vs. RT+/-ADT. Results: Overall, 1,987 (67.0%) and 980 (33.0%) patients received LT+/-ADT and ADT alone, respectively. In the LT+/-ADT group, 751 (37.8%) and 1,236 (62.2%) patients received RP+/-ADT and RT+/-ADT, respectively. In IVA, LT+/-ADT was associated with a significant overall mortality-free survival benefit (HR = 0.31; 95% CI = [0.13-0.74]; P= 0.007), when compared to ADT alone. At 5-year, overall mortality-free survival was 78.8% (95% CI: 74.1%-83.9%) vs. 49.2% (95% CI: 33.9%-71.4%) in the LT+/-ADT vs. ADT alone groups. When comparing RP+/-ADT vs. RT+/-ADT, IVA showed no significant difference in survival between the two treatment modalities (HR = 0.54; 95% CI = [0.19-1.52]; P= 0.24). Conclusions: Our study shows a significant overall mortality-free survival benefit for cN1 PCa patients who were treated with LT+/-ADT as compared to their counterparts treated with ADT alone. Conversely, no significant survival difference was observed between patients treated with RP+/-ADT vs. RT+/-ADT.

A Systematic Review of the Role of Definitive Local Treatment in Patients with Clinically Lymph Node-positive Prostate Cancer

2019 ◽  
Vol 2 (3) ◽  
pp. 294-301 ◽  
Author(s):  
Eugenio Ventimiglia ◽  
Thomas Seisen ◽  
Firas Abdollah ◽  
Alberto Briganti ◽  
Valerie Fonteyne ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
Lymph Node ◽  
Local Treatment ◽  
Node Positive ◽  
Lymph Node Positive

scholarly journals MP21-13 ASSESSING THE 20-YEAR OUTCOMES OF LYMPH NODE POSITIVE PROSTATE CANCER PATIENTS: A PLEA FOR LIFELONG FOLLOW-UP

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Marco Bandini ◽  
Nicola Fossati ◽  
Giorgio Gandaglia ◽  
Paolo Dell'Oglio ◽  
Emanuele Zaffuto ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Node Positive ◽  
Lymph Node Positive
Sign in / Sign up

Export Citation Format

Share Document