scholarly journals Cost–Utility Analysis of Antihemophilic Factor Rfviii-Fs for Secondary Prophylaxis Vs on-Demand Therapy In Severe Haemophilia A In Italy

2015 ◽  
Vol 18 (7) ◽  
pp. A671
Author(s):  
A Tagliaferri ◽  
A Coppola ◽  
S Amoresano ◽  
A Aiello ◽  
A D’Ausilio ◽  
...  
2002 ◽  
Vol 20 (11) ◽  
pp. 759-774 ◽  
Author(s):  
Alexander H. Miners ◽  
Caroline A. Sabin ◽  
Keith H. Tolley ◽  
Christine A. Lee

2016 ◽  
Vol 19 (7) ◽  
pp. A591
Author(s):  
Z Gharibnaseri ◽  
M Davari ◽  
A Cheraghali ◽  
P Eshghi ◽  
R Ravanbod ◽  
...  

Haemophilia ◽  
2010 ◽  
Vol 17 (1) ◽  
pp. 45-54 ◽  
Author(s):  
W.-S. LIOU ◽  
T.-C. TU ◽  
S.-N. CHENG ◽  
T.-Y. CHOU ◽  
C.-F. LEE ◽  
...  

2008 ◽  
Vol 99 (01) ◽  
pp. 71-76 ◽  
Author(s):  
Karin Kurnik ◽  
Frauke Friedrichs ◽  
Susan Halimeh ◽  
Anne Krümpel ◽  
Christoph Bidlingmaier ◽  
...  

SummaryPatients with severe haemophilia A (HA) can either be treated by regular FVIII infusions twice or three times per week (prophylaxis), or only in case of bleeding episodes (on-demand). Whereas prophylaxis reduces the number of bleeding episodes and may therefore prevent the development of haemophilic arthropathy, there is still a lot of controversy surrounding recommendations on age and dose at start of prophylactic regimens. The present database study was performed to investigate the role of primary versus secondary prophylaxis in HA children. The outcome variable was imaging-proven haemophilic joint damage. Forty-two children were initially treated with primary prophylaxis following the first bleeding episode, and were frequency-matched (year of birth, catchment area) to 67 pa- tients receiving “on-demand” therapy with an early switch to “secondary prophylaxis”. In multivariate analysis adjusted for the HA mutation type and the presence or absence of thrombophilia, the Pettersson score investigated at a median age of 12.5 years in joints with at least one documented bleeding episode was not significantly different between the two patient groups (p=0.944),and no statistically significant differences were found in patients with target joints (p=0.3), nor in children in whom synovitis had occurred (p=0.77). No conclusion can be drawn from the data presented herein whether primary prophylaxis or an early start of secondary prophylaxis is superior with respect to joint outcome in children with severe HA.


Haemophilia ◽  
2013 ◽  
Vol 19 (4) ◽  
pp. e228-e238 ◽  
Author(s):  
A. Farrugia ◽  
J. Cassar ◽  
M. C. Kimber ◽  
M. Bansal ◽  
K. Fischer ◽  
...  

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