Effects of Hepatic Artery Chemoembolization Using Cisplatin–lipiodol Suspension with Gelatin Sponge Particles on Swine Liver

Background The inferior phrenic artery (IPA) is the most common extrahepatic feeder for hepatocellular carcinoma (HCC) during transhepatic arterial chemoembolization (TACE). Purpose To compare the incidence of diaphragmatic weakness in patients with HCC after TACE of the right IPA conducted using either N-butyl cyanoacrylate (NBCA) or gelatin sponge particles. Material and Methods Medical records of 111 patients who underwent TACE of the right IPA using NBCA were retrospectively reviewed and compared with data from 135 patients with IPA embolization using gelatin sponge particles. Results The incidence of diaphragmatic weakness after the initial TACE procedure did not significantly differ between the groups (NBCA group 16.2%; gelatin sponge group 20.7%; P = 0.458). Five patients in the NBCA group and 11 in the gelatin sponge group showed spontaneous resolution of diaphragmatic weakness after a mean period of 3.5 months. Diaphragmatic weakness developed after the initial follow-up visit in 17 patients from the gelatin sponge group due to repeated TACE of the right IPA (mean 2.4 sessions; range 2–4 sessions), while it spontaneously developed without additional TACE procedures in one patient from the NBCA group. Permanent diaphragmatic weakness was less common in the NBCA than in the gelatin sponge group (12.6% and 25.2%, respectively; P = 0.017). The complete response rate did not significantly differ between the groups (NBCA group 16.2%; gelatin sponge group 25.9%; P = 0.065). Conclusion Use of NBCA rather than gelatin sponge particles for TACE of the right IPA resulted in a lower incidence of permanent diaphragmatic weakness.

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Vascular administration of adenoviral vector soaked in absorbable gelatin sponge particles (GSP) prolongs the transgene expression in hepatocytes

Cancer Gene Therapy ◽

10.1038/sj.cgt.7700744 ◽

2004 ◽

Vol 12 (2) ◽

pp. 116-121 ◽

Cited By ~ 5

Author(s):

Byeong-Ho Park ◽

Jin-Hwa Lee ◽

Jin-Sook Jeong ◽

Seo-Hee Rha ◽

Seung-Eun Kim ◽

...

Keyword(s):

Transgene Expression ◽

Adenoviral Vector ◽

Gelatin Sponge ◽

Gelatin Sponge Particles

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Ruptured aneurysm of the hepatic artery: a mismatching diagnosis

Italian Journal of Medicine ◽

10.4081/itjm.2009.175 ◽

2013 ◽

pp. 175-178

Author(s):

Vincenzo Bua ◽

Lorenzo Marsigli ◽

Roberto Nardi ◽

Anna Maria Trivella ◽

Salvatore Isceri ◽

...

Keyword(s):

Hepatic Artery ◽

Ct Scanning ◽

Gelatin Sponge ◽

Contrast Enhanced Ct ◽

Life Saving ◽

Contrast Enhanced ◽

Enhanced Ct ◽

Threatening Condition ◽

Life Threatening ◽

Intraabdominal Hemorrhage

Background: Hepatic aneurysms are extremely rare with very few cases reported, and most have been source of misdiagnosis and clinical pitfalls in emergency medicine. Presentation with intraabdominal hemorrhage is associated with a high mortality rate. Case report: We report the case of an adult male, referred for a severe acute pain in the left lower chest-upper quadrant abdomen pain. We present multislice contrast-enhanced CT-scanning and angiographic findings, and a life-saving emergency trancatheter embolization, using fragments of absorbable gelatin sponge. Emergency doctors should consider ruptured hepatic artery aneurysms in the differential diagnosis of acute abdominal pain and promptly cooperate with endovascular specialists to treat this life-threatening condition.

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