scholarly journals 03:09 PM Abstract No. 422 Early prediction of tumor response using contrast-enhanced ultrasonography in intra-arterial therapy by micellar nanoparticles in a rat liver tumor model

2019 ◽  
Vol 30 (3) ◽  
pp. S185
Author(s):  
R. Taiji ◽  
H. Nishiofuku ◽  
T. Tanaka ◽  
K. Minamiguchi ◽  
Y. Fukuoka ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Tumor ◽  
Tumor Response ◽  
Tumor Model ◽  
Early Prediction ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography ◽  
Micellar Nanoparticles

scholarly journals Useful Parameters in Dynamic Contrast-enhanced Ultrasonography for Identifying Early Response to Chemotherapy in a Rat Liver Tumor Model

2021 ◽  
Vol 11 ◽  
pp. 15
Author(s):  
Ryosuke Taiji ◽  
Hideyuki Nishiofuku ◽  
Toshihiro Tanaka ◽  
Kiyoyuki Minamiguchi ◽  
Yasushi Fukuoka ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Rat Liver ◽  
Liver Tumor ◽  
Tumor Size ◽  
Tumor Model ◽  
Early Response ◽  
K Value ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography

Objectives: The objective of the study is to determine a parameter on the time-intensity curve (TIC) of dynamic contrast-enhanced ultrasonography (DCE-US) that best correlates with tumor growth and to evaluate whether the parameter could correlate with the early response to irinotecan in a rat liver tumor model. Material and Methods: Twenty rats with tumors were evaluated (control: Saline, n = 6; treatment: Irinotecan, n = 14) regarding four parameters from TIC: Peak intensity (PI), k value, slope (PI × k), and time to peak (TTP). Relative changes in maximum tumor diameter between day 0 and 10, and parameters in the first 3 days were evaluated. The Mann-Whitney U-test was used to compare differences in tumor size and other parameters. Pearson’s correlation coefficients (r) between tumor size and parameters in the control group were calculated. In the treatment group, relative changes of parameters in the first 3 days were compared between responder and non-responder (<20% and ≥20% increase in size on day 10, respectively). Results: PI, k value, PI × k, and TTP significantly correlated with tumor growth (r = 0.513, 0.911, 0.665, and 0.741, respectively). The mean RC in k value among responders (n = 6) was significantly lower than non-responders (n = 8) (mean k value, 4.96 vs. 72.5; P = 0.003). Conclusion: Parameters of DCE-US could be a useful parameter for identifying early response to irinotecan.

Intraarterial Therapy Using Micellar Nanoparticles Incorporating SN-38 in a Rabbit Liver Tumor Model

2017 ◽  
Vol 28 (3) ◽  
pp. 457-464 ◽  
Author(s):  
Hideyuki Nishiofuku ◽  
Toshihiro Tanaka ◽  
Yasushi Fukuoka ◽  
Takeshi Sato ◽  
Tetsuya Masada ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Tumor Model ◽  
Rabbit Liver ◽  
Intraarterial Therapy ◽  
Micellar Nanoparticles

Biodistribution and Bioactivity of Tetra-pegylated Meta-tetra(hydroxyphenyl)chlorin Compared to Native Meta-tetra(hydroxyphenyl)chlorin in a Rat Liver Tumor Model

2007 ◽  
Vol 71 (2) ◽  
pp. 211-217 ◽  
Author(s):  
Jeroen P. Rovers ◽  
Anne E. Saarnak ◽  
Martin Jode ◽  
Hendricus J. C. M. Sterenborg ◽  
Onno T. Terpstra ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Tumor ◽  
Tumor Model

scholarly journals A Method for Assessing the Microvasculature in a Murine Tumor Model Using Contrast-Enhanced Ultrasonography

2008 ◽  
Vol 27 (12) ◽  
pp. 1699-1709 ◽  
Author(s):  
Mary E. Loveless ◽  
Xia Li ◽  
Jessica Huamani ◽  
Andrej Lyshchik ◽  
Benoit Dawant ◽  
...  
Keyword(s):  
Tumor Model ◽  
Murine Tumor ◽  
Murine Tumor Model ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography
Sign in / Sign up

Export Citation Format

Share Document