Simple chiral auxiliary-assisted resolution of 2-(3,5-di-tert-butyl-4-hydroxyphenyl)propionic acid

2010 ◽  
Vol 20 (5) ◽  
pp. 291-292 ◽  
Author(s):  
Grigory A. Nikiforov ◽  
Orudzh G. Nabiev ◽  
Ivan I. Chervin ◽  
Remir G. Kostyanovsky
Keyword(s):  
Propionic Acid ◽  
Chiral Auxiliary ◽  
Tert Butyl

scholarly journals Paradoxical Anti-Epileptic Effects of a GluR5 Agonist of Kainate Receptors

2002 ◽  
Vol 88 (1) ◽  
pp. 523-527 ◽  
Author(s):  
Ilgam Khalilov ◽  
June Hirsch ◽  
Rosa Cossart ◽  
Yehezkel Ben-Ari
Keyword(s):  
Propionic Acid ◽  
Therapeutic Approach ◽  
Hippocampal Neurons ◽  
Selective Excitation ◽  
Kainate Receptors ◽  
Kainate Receptor ◽  
Tert Butyl ◽  
Principal Cells ◽  
Selective Agonist

Kainate generates in adult hippocampal neurons a seizure but also a massive excitation of interneurons and a dramatic increase of the inhibitory drive that impinges on principal cells. This “overinhibition” is largely mediated by GluR5-containing kainate receptors that are enriched on interneurons. Here, using the neonatal intact hippocampus in vitro and the triple chamber, we first show that this mechanism is fully operative in neonatal neurons. We then report that application to one hippocampus of ( RS)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid—a relatively selective agonist of GluR5 containing kainate receptors—depresses the propagation of seizure generated in the opposite hippocampus by a convulsive agent. We conclude that the selective excitation of interneurons by GluR5-containing kainate receptor agonists opens a new therapeutic approach for the epilepsies.

Synthesis of (S)-2-Amino-3-(3-tert-butyl-5-oxo-2H-isoxazol-4-yl)propionic Acid

1995 ◽  
Vol 60 (10) ◽  
pp. 3184-3188 ◽  
Author(s):  
Mohamed Atfani ◽  
William D. Lubell
Keyword(s):  
Propionic Acid ◽  
Tert Butyl

Resolution, absolute stereochemistry, and enantiopharmacology of the GluR1-4 and GluR5 antagonist 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid

Chirality ◽  
1999 ◽  
Vol 11 (10) ◽  
pp. 752-759 ◽  
Author(s):  
Eva H. M�ller ◽  
Jan Egebjerg ◽  
Lotte Brehm ◽  
Tine B. Stensb�l ◽  
Tommy N. Johansen ◽  
...  
Keyword(s):  
Propionic Acid ◽  
Tert Butyl ◽  
Absolute Stereochemistry

ChemInform Abstract: Conformational Control in the SuperQuat Chiral Auxiliary 5,5-Dimethyl-4-isopropyloxazolidin-2-one Induces the iso-Propyl Group to Mimic a tert-Butyl Group.

ChemInform ◽  
2001 ◽  
Vol 32 (1) ◽  
pp. no-no
Author(s):  
Steven D. Bull ◽  
Stephen G. Davies ◽  
Min-Suk Key ◽  
Rebecca L. Nicholson ◽  
Edward D. Savory
Keyword(s):  
Chiral Auxiliary ◽  
Conformational Control ◽  
Tert Butyl ◽  
Butyl Group ◽  
Tert Butyl Group
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