Lesson of regulatory anatomy: Using integrated functional genomics to dissect the X-inactivation center

2022 ◽  
Vol 82 (1) ◽  
pp. 10-12
Author(s):  
Elphège P. Nora
Keyword(s):  
Functional Genomics ◽  
X Inactivation ◽  
Inactivation Center

First female with Allan-Herndon-Dudley syndrome and partial deletion of X-inactivation center

Neurogenetics ◽  
2021 ◽  
Author(s):  
Juan F. Quesada-Espinosa ◽  
Lucía Garzón-Lorenzo ◽  
José M. Lezana-Rosales ◽  
María J. Gómez-Rodríguez ◽  
María T. Sánchez-Calvin ◽  
...  
Keyword(s):  
X Inactivation ◽  
Partial Deletion ◽  
Inactivation Center

Genetic mapping in the region of the mouse X-inactivation center

Genomics ◽  
1990 ◽  
Vol 7 (4) ◽  
pp. 566-572 ◽  
Author(s):  
J.T. Keer ◽  
R.M.J. Hamvas ◽  
N. Brockdorff ◽  
D. Page ◽  
S. Rastan ◽  
...  
Keyword(s):  
Genetic Mapping ◽  
X Inactivation ◽  
Inactivation Center

scholarly journals Identification of an Imprinted Gene Cluster in the X-Inactivation Center

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e71222 ◽  
Author(s):  
Shin Kobayashi ◽  
Yasushi Totoki ◽  
Miki Soma ◽  
Kazuya Matsumoto ◽  
Yoshitaka Fujihara ◽  
...  
Keyword(s):  
Gene Cluster ◽  
X Inactivation ◽  
Imprinted Gene ◽  
Inactivation Center

Getting to the center of X-chromosome inactivation: the role of transgenesThis paper is one of a selection of papers published in this Special Issue, entitled 30th Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal’s usual peer review process.

2009 ◽  
Vol 87 (5) ◽  
pp. 759-766 ◽  
Author(s):  
Jakub Minks ◽  
Carolyn J. Brown
Keyword(s):  
X Chromosome ◽  
Peer Review Process ◽  
Regulatory Elements ◽  
X Chromosome Inactivation ◽  
X Inactivation ◽  
Chromosome Inactivation ◽  
Xist Expression ◽  
Inactivation Center ◽  
Xist Rna ◽  
Epigenetic Phenomenon

X-chromosome inactivation is a fascinating epigenetic phenomenon that is initiated by expression of a noncoding (nc)RNA, XIST, and results in transcriptional silencing of 1 female X. The process requires a series of events that begins even before XIST expression, and culminates in an active and a silent X within the same nucleus. We will focus on the role that transgenic systems have served in the current understanding of the process of X-chromosome inactivation, both in the initial delineation of an active and inactive X, and in the function of the XIST RNA. X inactivation is strictly cis-limited; recent studies have revealed elements within the X-inactivation center, the region required for inactivation, that are critical for the initial regulation of Xist expression and chromosome pairing. It has been revealed that the X-inactivation center contains a remarkable compendium of cis-regulatory elements, ncRNAs, and trans-acting pairing regions. We review the functional componentry of the X-inactivation center and discuss experiments that helped to dissect the XIST/Xist RNA and its involvement in the establishment of facultative heterochromatin.

Replication timing of the human X-inactivation center (XIC) region: correlation with chromosome bands

Gene ◽  
2000 ◽  
Vol 252 (1-2) ◽  
pp. 163-172 ◽  
Author(s):  
Yoshihisa Watanabe ◽  
Toyoaki Tenzen ◽  
Yasuhiko Nagasaka ◽  
Hidetoshi Inoko ◽  
Toshimichi Ikemura
Keyword(s):  
Replication Timing ◽  
X Inactivation ◽  
Inactivation Center ◽  
Chromosome Bands

Mental retardation and Ullrich-Turner syndrome in cases with 45,X/46,X,+ mar: Additional support for the loss of the X-inactivation center hypothesis

1994 ◽  
Vol 52 (2) ◽  
pp. 136-145 ◽  
Author(s):  
Heath Cole ◽  
Bing Huang ◽  
Bonnie Anne Salbert ◽  
Judith Brown ◽  
Patricia N. Howard-Peebles ◽  
...  
Keyword(s):  
Mental Retardation ◽  
Turner Syndrome ◽  
X Inactivation ◽  
Inactivation Center ◽  
Additional Support

Low-Copy-Number Human Transgene Is Recognized as an X Inactivation Center in Mouse ES Cells, but Fails to Induce cis-Inactivation in Chimeric Mice

Genomics ◽  
2001 ◽  
Vol 71 (2) ◽  
pp. 156-162 ◽  
Author(s):  
Barbara R. Migeon ◽  
Holly Winter ◽  
Ethan Kazi ◽  
Ashis K. Chowdhury ◽  
Aisha Hughes ◽  
...  
Keyword(s):  
Copy Number ◽  
Es Cells ◽  
X Inactivation ◽  
Chimeric Mice ◽  
Mouse Es Cells ◽  
Inactivation Center ◽  
Low Copy Number
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