Pharmacokinetics and pharmacodynamics of intranasally administered selegiline nanoparticles with improved brain delivery in Parkinson's disease

2018 ◽  
Vol 14 (8) ◽  
pp. 2609-2618 ◽  
Author(s):  
Vinay Sridhar ◽  
Ram Gaud ◽  
Amrita Bajaj ◽  
Sarika Wairkar
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Brain Delivery ◽  
Pharmacokinetics And Pharmacodynamics

GOCOVRI® (amantadine) extended-release capsules in Parkinson's disease

2021 ◽  
Author(s):  
Thomas Müller
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Extended Release ◽  
Motor Behavior ◽  
Brain Delivery ◽  
Antiviral Compound ◽  
Once Daily ◽  
Beneficial Effects ◽  
Central Monoamine ◽  
Preventive Effects

Amantadine is an old, antiviral compound, which moderately improves motor behavior in Parkinson's disease. Its current resurgence results from an innovative, delayed uptake and extended release amantadine hydrochloride capsule, given at bedtime once daily. It is the only approved compound for reduction of involuntary movements, so called dyskinesia, in fluctuating orally levodopa treated patients. It additionally ameliorates ‘off’-intervals characterized by impaired motor behavior. These beneficial effects result from higher and more continuous brain delivery of amantadine. Future clinical research is warranted on preventive effects of this amantadine capsule combined with enzyme blockers of central monoamine oxidase B and peripheral catechol-O-methyltransferase on motor complications in orally levodopa treated patients, as all these pharmacological principles support the concept of continuous dopamine substitution.

scholarly journals Pharmacokinetics and pharmacodynamics of a single dose Nilotinib in individuals with Parkinson's disease

2019 ◽  
Vol 7 (2) ◽  
pp. e00470 ◽  
Author(s):  
Fernando L. Pagan ◽  
Michaeline L. Hebron ◽  
Barbara Wilmarth ◽  
Yasar Torres‐Yaghi ◽  
Abigail Lawler ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Single Dose ◽  
Pharmacokinetics And Pharmacodynamics

scholarly journals Effective GDNF brain delivery using microspheres—A promising strategy for Parkinson's disease

2009 ◽  
Vol 135 (2) ◽  
pp. 119-126 ◽  
Author(s):  
E. Garbayo ◽  
C.N. Montero-Menei ◽  
E. Ansorena ◽  
J.L. Lanciego ◽  
M.S. Aymerich ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Brain Delivery ◽  
Promising Strategy

Nanoparticles Mediating the Sustained Puerarin Release Facilitate Improved Brain Delivery to Treat Parkinson’s Disease

2019 ◽  
Vol 11 (48) ◽  
pp. 45276-45289 ◽  
Author(s):  
Tongkai Chen ◽  
Wei Liu ◽  
Sha Xiong ◽  
Dongli Li ◽  
Shuhuan Fang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Brain Delivery
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