Unusual Cases of Anti-SRP Necrotizing Myopathy with Predominant Distal Leg Weakness and Atrophy

2021 ◽  
Author(s):  
Orly Moshe-Lilie ◽  
Daniela Ghetie ◽  
George Banks ◽  
Barry G. Hansford ◽  
Nizar Chahin
Keyword(s):  
Necrotizing Myopathy ◽  
Leg Weakness

Isolated Distal Leg Weakness due to a Small Cerebral Infarction Masquerading as a Spinal Lesion

2007 ◽  
Vol 41 (3) ◽  
pp. 182 ◽  
Author(s):  
In Bo Han ◽  
Jung Yong Ahn ◽  
Young Sun Chung ◽  
Sang Sup Chung
Keyword(s):  
Cerebral Infarction ◽  
Spinal Lesion ◽  
Leg Weakness

scholarly journals Back pain and leg weakness

2011 ◽  
Vol 195 (8) ◽  
pp. 454-457 ◽  
Author(s):  
Timothy J Kleinig ◽  
Brian P Brophy ◽  
Chris G Maher
Keyword(s):  
Back Pain ◽  
Leg Weakness

scholarly journals SHOULD LEG WEAKNESS IN GROWING CHICKS BE CALLED RICKETS?

1926 ◽  
Vol 69 (2) ◽  
pp. 289-294
Author(s):  
J.S. Hughes ◽  
R.W. Titus
Keyword(s):  
Leg Weakness

scholarly journals LEG Weakness In Pigs

1974 ◽  
Vol 15 (4) ◽  
pp. 555-573 ◽  
Author(s):  
Trygue Grøndalen
Keyword(s):  
Leg Weakness

scholarly journals Statin-Induced Autoimmune Necrotizing Myopathy

2021 ◽  
Vol 12 ◽  
pp. 215013272110287
Author(s):  
Sahani Jayatilaka ◽  
Kunal Desai ◽  
Swarup Rijal ◽  
Debra Zimmerman
Keyword(s):  
Renal Failure ◽  
Statin Therapy ◽  
Initial Presentation ◽  
Autoimmune Reaction ◽  
Necrotizing Myopathy ◽  
Starting Dose ◽  
Key Enzyme ◽  
Risk Patients ◽  
Autoimmune Myopathy ◽  
Coa Reductase

Statin therapy is a widely prescribed medication class for hypercholesterolemia. In statin-induced autoimmune myopathy, genetically predisposed and at-risk patients can develop antibodies against hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the key enzyme in the production of cholesterol. As a result, an autoimmune reaction causing weakness, myalgia, with possible severe rhabdomyolysis, renal failure, and myonecrosis also can occur. A 73-year-old female presented to clinic with myalgia and fatigue. She was on atorvastatin 20 mg/day for over 1 year, which she stopped 1 week prior to her initial presentation. Patient did experience rhabdomyolysis as well as a transaminitis. She underwent an autoimmune workup which was positive for HMG-CoA reductase antibodies. Patient was initially treated on a prednisone taper, starting dose 50 mg/day. Without remission of symptoms, methotrexate 15 mg/week was initiated.

Genetics of Leg Weakness in Boars at the Danish Pig Breeding Stations

1990 ◽  
Vol 40 (1) ◽  
pp. 59-69 ◽  
Author(s):  
Bente J⊘rgensen ◽  
Thorkild Vestergaard
Keyword(s):  
Leg Weakness
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