Impact of contralateral lymph nodal involvement and extranodal extension on survival of surgically managed HPV-positive oropharyngeal cancer staged with the AJCC eighth edition

Oral Oncology ◽  
2019 ◽  
Vol 99 ◽  
pp. 104447 ◽  
Author(s):  
Joseph A. Miccio ◽  
Vivek Verma ◽  
Jacqueline Kelly ◽  
Benjamin H. Kann ◽  
Yi An ◽  
...  
Keyword(s):  
Oropharyngeal Cancer ◽  
Nodal Involvement ◽  
Extranodal Extension ◽  
Eighth Edition

scholarly journals Analysis of PET parameters as prognosticators of survival and tumor extent in Oropharyngeal Cancer treated with surgery and postoperative radiotherapy

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kyu Hye Choi ◽  
Jin Ho Song ◽  
Eun Young Park ◽  
Ji Hyun Hong ◽  
Ie Ryung Yoo ◽  
...  
Keyword(s):  
Oropharyngeal Cancer ◽  
Postoperative Radiotherapy ◽  
Metabolic Tumor Volume ◽  
Total Lesion Glycolysis ◽  
Primary Lesion ◽  
Depth Of Invasion ◽  
Extranodal Extension ◽  
Positron Emission ◽  
Regional Node ◽  
Tumor Extent

Abstract Background Positron-emission tomography (PET) is widely used to detect malignancies, but consensus on its prognostic value in oropharyngeal cancer has not been established. The purpose of this study was to analyze the PET parameters associated with tumor extent and survival in resectable oropharyngeal cancer. Methods The PET parameters in oropharyngeal cancer patients with regional node metastasis who underwent surgery and postoperative radiotherapy between January 2005 and January 2019 were analyzed. We calculated the SUVmax, tumor-to-liver ratio (TLR), metabolic tumor volume (MTV, volume over SUV 2.5), and total lesion glycolysis (TLG, MTV x mean SUV) of the primary lesion and metastatic nodes. Histologic findings, patient survival, and recurrence were reviewed in the medical records. Results Fifty patients were included, and the PET parameters were extracted for 50 primary lesions and 104 nodal lesions. In the survival analysis, MTV and TLG of the primary lesions showed significant differences in overall survival (OS) and recurrence-free survival (RFS). In the multiple regression analysis, TLG of the primary lesion was associated with the depth of invasion (DOI). MTV of the nodes was a significant factor affecting extranodal extension (ENE). Conclusions PET parameters could be related with OS, RFS, DOI of the primary tumor, and ENE. PET would be expected to be a useful diagnostic tool as a prognosticator of survival and pathologic findings in oropharyngeal cancer.

scholarly journals OC-007 Radiologic extranodal extension portends worse outcome in TNM-8 cT1-T2N1 HPV + oropharyngeal cancer

2019 ◽  
Vol 132 ◽  
pp. 7-8 ◽  
Author(s):  
S.H.S. Huang ◽  
E. Yu ◽  
A. Billfalk-Kelly ◽  
J. Su ◽  
J. Waldron ◽  
...  
Keyword(s):  
Oropharyngeal Cancer ◽  
Extranodal Extension

Radiographic Imaging Does Not Reliably Predict Macroscopic Extranodal Extension in Human Papilloma Virus-Associated Oropharyngeal Cancer

ORL ◽  
2018 ◽  
Vol 80 (2) ◽  
pp. 85-95 ◽  
Author(s):  
Mihir R. Patel ◽  
Patricia A. Hudgins ◽  
Jonathan J. Beitler ◽  
Kelly R. Magliocca ◽  
Christopher C. Griffith ◽  
...  
Keyword(s):  
Human Papilloma Virus ◽  
Oropharyngeal Cancer ◽  
Radiographic Imaging ◽  
Papilloma Virus ◽  
Extranodal Extension

scholarly journals Value of transoral surgery for human papillomavirus-mediated oropharyngeal cancer: validation of a new staging system in Japanese patients

2019 ◽  
Vol 47 (10) ◽  
pp. 5048-5059 ◽  
Author(s):  
Eiko Kimura ◽  
Koji Araki ◽  
Masayuki Tomifuji ◽  
Yuya Tanaka ◽  
Kosuke Uno ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Oropharyngeal Cancer ◽  
Poor Prognosis ◽  
Staging System ◽  
Japanese Patients ◽  
Clinical Staging ◽  
Transoral Surgery ◽  
Seventh Edition ◽  
Eighth Edition ◽  
Ajcc Staging

Objective This study aimed to validate new staging of Japanese patients with human papillomavirus-mediated oropharyngeal cancer (HPV+-OPC) and the effectiveness of transoral surgery. Methods Fifty-three patients with HPV+-OPC were classified according to the seventh and eighth editions of the American Joint Committee on Cancer (AJCC) staging, along with assessment of prognosis, smoking and alcohol status, and treatment outcome. Transoral videolaryngoscopic surgery (TOVS) was performed as transoral surgery. Results The 5-year overall survival (OS) rate was 77.3% in all patients. Five-year OS rates of seventh edition staging were as follows: II, 100%; III, 100%; IVa, 75.9%; and IVb and IVc, 0%. Five-year OS rates of the eighth edition clinical staging were as follows: I, 89.3%; II, 88.9%; III, 46.3%; and IV, 0%. In non-smoking and smoking patients with HPV+-OPC, the 5-year OS rates were 90.9% and 70.7%, respectively. TOVS was used for treating 20 smokers with HPV+-OPC (5-year OS: 85.7%), while 12 were treated with chemoradiotherapy (5-year OS: 75.0%). Conclusions The eighth edition of the AJCC determines the prognosis of HPV+-OPC more accurately than the seventh edition in clinical staging. Smokers with HPV+-OPC have a poor prognosis, but TOVS might improve the prognosis.

Prognostic Significance of Smoking in Human Papillomavirus– Positive Oropharyngeal Cancer Under American Joint Committee on Cancer Eighth Edition Stage

2020 ◽  
Vol 130 (8) ◽  
pp. 1961-1966
Author(s):  
Smrithi Chidambaram ◽  
Erik R. Nakken ◽  
William Kennedy ◽  
Wade L. Thorstad ◽  
Stephanie Y. Chen ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Oropharyngeal Cancer ◽  
Prognostic Significance ◽  
American Joint Committee ◽  
Eighth Edition
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