Japanese Patients
Recently Published Documents


TOTAL DOCUMENTS

8413
(FIVE YEARS 3190)

H-INDEX

97
(FIVE YEARS 36)

2021 ◽  
Vol 27 (4) ◽  
pp. 602-611
Author(s):  
Sayuri Yamamoto ◽  
Yurika Kawamura ◽  
Kazuhiro Yamamoto ◽  
Yoshiharu Yamaguchi ◽  
Yasuhiro Tamura ◽  
...  

2021 ◽  
Author(s):  
Maho Kumagai ◽  
Mitsuji Nagahama ◽  
Yumiko Akamine ◽  
Tomoko Ozeki ◽  
Akifumi Suzuki ◽  
...  

Abstract The purpose of this study was to investigate the relationships among plasma concentrations (C0) of lenvatinib, angiopoietin (Ang)-1 and Ang-2, and clinical responses to lenvatinib therapy in thyroid cancer patients. The median change rates of Ang-1 and Ang-2 at 1 month after treatment from baseline in all patients were − 15.3% and − 48.4%, respectively. However, the change of Ang-1 and Ang-2 at 1 month from baseline did not correlate with lenvatinib C0. In patients with partial response (PR) and stable disease to lenvatinib, Ang-2 at 1 month were significantly lower than Ang-2 at baseline (P < 0.001 and P < 0.05, respectively), but were not significantly lower in patients with progressive disease. The area under the ROC for PR prediction was 0.667, giving the best sensitivity (69.2%) and specificity (73.9%) at a threshold of the change rate of Ang-2 of -49.83%. In patients who continued treatment with lenvatinib for 1 year, Ang-2 at 1 month and 1 year were significantly lower than those at baseline (each P < 0.001). The change of Ang-2 at 1 month after treatment from baseline rather than simply the Ang-2 level at baseline may be important as a biomarker of the inhibitory effect of angiogenesis by lenvatinib.


Author(s):  
Ryuichi Ohta ◽  
Akinori Ueno ◽  
Chiaki Sano

Help-seeking behaviors (HSBs) refer to how people use lay and medical care to address their symptoms and diseases. The COVID-19 pandemic may have changed older, rural patients’ preferences and experiences regarding HSBs, thereby, affecting the comprehensiveness of medical support for communities. This study identified changes in the comprehensiveness of medical care for older, rural patients, who are often dependent on others for accessing medical services. This observational study was performed with patients who lived in Unnan City. Patients’ dependency and changes in comprehensiveness of medical services were assessed and calculated. The total usage of medical care decreased from 2018 to 2020 at all medical care levels. The proportion of patients who received comprehensive care was higher in 2020 than in 2018, at all care levels. At care dependent levels 3 to 5, the differences in the proportions were statistically significant. This study illustrates an association between the COVID-19 pandemic and the proportion of comprehensiveness of medical care among older rural patients with a decrease in medical care usage. Moreover, an improved proportion of comprehensiveness of medical care leads to appropriate HSBs. Going forward, HSBs and patient-centered care should be promoted by policy makers.


2021 ◽  
Author(s):  
Kensaku Nishihira ◽  
Yoshisato Shibata

Author(s):  
Hiroo Yokozeki ◽  
Tomoko Fujimoto ◽  
Shunsuke Wanatabe ◽  
Shuhei Ogawa ◽  
Chie Fujii

Author(s):  
Sayuri Sable-Morita ◽  
Yuki Arai ◽  
Sanae Takanashi ◽  
Keita Aimoto ◽  
Mika Okura ◽  
...  

We aimed to develop and test the reliability and validity of a foot care self-management assessment tool for older Japanese patients with diabetes. In this cross-sectional observational study, which was carried out according to the Strengthening the Reporting of Observational Studies in Epidemiology guidelines, additional items were developed and selected to reflect older Japanese patients’ needs a thorough investigation with experts in diabetes and geriatrics. A total of 200 older patients with diabetes in a foot care outpatient clinic were included in the study to finalize the scale items and verify the scale's reliability and validity. A factor analysis yielded a 4-factor, 9-item scale. Factors 1 to 4 were “skin condition” (3 items), “nail clipping” (2 items), “attention to wounds” (2 items), and “relationships with others” (2 items). The Cronbach's α coefficients for the 4 factors were .852, .900, .820, and .571, respectively. The overall scale was 0.797, indicating good internal consistency. Spearman's correlation coefficients for each of the 4 factors with the scale's total score showed good stability; all correlations were significant. In Japan's super-aged society, it is important to focus on foot care practices among older adults and to promote good foot care practices among early older adults so that they can practice self-care at home. Therefore, a scale for comprehensively evaluating foot care in elderly patients with diabetes is needed. The Foot Care Scale for Older Diabetics could be useful as a tool for assessing the ability to self-manage foot care in older Japanese patients with diabetes.


Author(s):  
Shinsuke Iida ◽  
Tohru Izumi ◽  
Takuya Komeno ◽  
Yasuhito Terui ◽  
Takaaki Chou ◽  
...  

Abstract Background TOURMALINE-MM1 was a global study that demonstrated a significant improvement in progression-free survival with ixazomib plus lenalidomide and dexamethasone compared with placebo plus lenalidomide and dexamethasone, in patients with relapsed and/or refractory multiple myeloma. The current study was conducted to evaluate further the efficacy and safety of ixazomib plus lenalidomide and dexamethasone in Japanese patients. Methods This phase 2, open-label, single-arm, multicenter study enrolled patients aged ≥ 20 years with relapsed and/or refractory multiple myeloma at 16 sites in Japan. Patients refractory to lenalidomide or proteasome inhibitor-based therapy at any line were excluded. The primary endpoint was the rate of very good partial response or better in the response-evaluable analysis set. Secondary endpoints were progression-free survival, overall response rate, duration of response, time to progression, overall survival and safety. Results In total, 34 patients were enrolled. The rate of very good partial response or better was 50.0% (95% confidence interval 31.9–68.1) and the overall response rate was 84.4% (95% confidence interval 67.2–94.7). Median progression-free survival was 22.0 months (95% confidence interval 17.3–not evaluable) and median overall survival was not estimable. The safety profile of ixazomib plus lenalidomide and dexamethasone in this study was similar to that in the TOURMALINE-MM1 study. Conclusions The efficacy and safety of ixazomib plus lenalidomide and dexamethasone in Japanese patients with relapsed and/or refractory multiple myeloma are comparable with reported TOURMALINE-MM1 study results. Clinicaltrials.gov identifier NCT02917941; date of registration September 28, 2016.


Author(s):  
Eiji Hisamatsu

Author(s):  
Hideki Takeshita ◽  
Kojiro Tachibana ◽  
Hironori Sugiyama ◽  
Makoto Kagawa ◽  
Akihiro Yano ◽  
...  

2021 ◽  
Vol 15 (6) ◽  
Author(s):  
Atsushi Yamada ◽  
Yui Matsuoka ◽  
Sachiko Minamiguchi ◽  
Yoshihiro  Yamamoto ◽  
Tomohiro  Kondo ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document