Percutaneous Tracheotomy in Bone Marrow Transplant Patients With Severe Thrombocytopenia

2005 ◽  
Vol 133 (3) ◽  
pp. 377-380 ◽  
Author(s):  
Arie Gordin ◽  
Aviram Netzer ◽  
Henry Zvi Joachims ◽  
Avishay Golz

OBJECTIVE: Evaluation of percutaneous tracheotomy in bone marrow transplant patients with severe thrombocytopenia. DESIGN: A retrospective outcome study. PATIENTS: A retrospective study of 26 percutaneous tracheotomies was performed at the Bone Marrow Transplant Unit, Rambam Medical Center, Haifa, Israel. Age, sex, underlying disease, reason for intubation, complete blood count, coagulation profile, and the incidence of renal failure were collected. All patients received 6 units of platelets one hour prior to the procedure. RESULTS: The mean platelets count was 14,300 ± 5500. Twenty-five of the 26 percutaneous tracheotomies were completed successfully, without any intraoperative complications. One patient suffered from moderate bleeding during the procedure, which was immediately stopped and converted to open tracheotomy. In the postoperative period 4 patients suffered from mild bleeding around the stoma, which was managed conservatively. No other late complications were encountered. CONCLUSIONS: Percutaneous tracheotomy can be safely performed in patients with severe thrombocytopenia when the surgeon and anesthesiologist are experienced in the procedure, and platelets are given perioperatively.

Author(s):  
Cameron K. Ledford ◽  
Alexander R. Vap ◽  
Michael P. Bolognesi ◽  
Samuel S. Wellman

2021 ◽  
Vol 30 ◽  
pp. S198-S199
Author(s):  
P. Emerson ◽  
S. Mahendran ◽  
L. Stefani ◽  
T. Deshmukh ◽  
S. Trivedi ◽  
...  

2004 ◽  
Vol 50 (2) ◽  
pp. 306-312 ◽  
Author(s):  
Stefan S Biel ◽  
Andreas Nitsche ◽  
Andreas Kurth ◽  
Wolfgang Siegert ◽  
Muhsin Özel ◽  
...  

Abstract Background: We studied electron microscopy (EM) as an appropriate test system for the detection of polyomavirus in urine samples from bone marrow transplant patients. Methods: We evaluated direct EM, ultracentrifugation (UC) before EM, and solid-phase immuno-EM (SPIEM). The diagnostic accuracy of EM was studied by comparison with a real-time PCR assay on 531 clinical samples. Results: The detection rate of EM was increased by UC and SPIEM. On 531 clinical urine samples, the diagnostic sensitivity of EM was 47% (70 of 149) with a specificity of 100%. We observed a linear relationship between viral genome concentration and the proportion of urine samples positive by EM, with a 50% probability for a positive EM result for urine samples with a polyomavirus concentration of 106 genome-equivalents (GE)/mL; the probability of a positive EM result was 0% for urine samples with <103 GE/mL and 100% for urine samples containing 109 GE/mL. Conclusions: UC/EM is rapid and highly specific for polyomavirus in urine. Unlike real-time PCR, EM has low sensitivity and cannot quantify the viral load.


BMJ ◽  
1971 ◽  
Vol 1 (5739) ◽  
pp. 18-23 ◽  
Author(s):  
C. O. Solberg ◽  
H. J. Meuwissen ◽  
R. N. Needham ◽  
R. A. Good ◽  
J. M. Matsen

1998 ◽  
Vol 37 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Sohail Khattak ◽  
John W. Rogan ◽  
E. Fred Saunders ◽  
Jochen G. W. Theis ◽  
Gerald S. Arbus ◽  
...  

1993 ◽  
Vol 24 (2) ◽  
pp. 152-159
Author(s):  
Kay Washington ◽  
William Peters ◽  
Marcia R. Gottfried

1989 ◽  
Vol 17 (2) ◽  
pp. 140-143 ◽  
Author(s):  
J. A. Russell ◽  
W. B. Blahey ◽  
T. A. Stuart ◽  
G. Edwards ◽  
R. T. Card

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