Comparative ex vivo infection with Trypanosoma cruzi and Toxoplasma gondii of human, canine and ovine placenta: Analysis of tissue damage and infection efficiency

2020 ◽  
Vol 76 ◽  
pp. 102065 ◽  
Author(s):  
Ana Liempi ◽  
Christian Castillo ◽  
Lisvaneth Medina ◽  
Norbel Galanti ◽  
Juan Diego Maya ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Trypanosoma Cruzi ◽  
Tissue Damage ◽  
Ex Vivo ◽  
Infection Efficiency ◽  
Ovine Placenta

Ex vivo infection with Toxoplasma gondii and Trypanosoma cruzi in human, dog and sheep placental explants induces tissue damage

Placenta ◽  
2017 ◽  
Vol 57 ◽  
pp. 268-269
Author(s):  
Ana Liempi ◽  
Castillo Castillo ◽  
Ileana Carrillo ◽  
Lisvaneth Medina ◽  
Rhonda Veas ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Trypanosoma Cruzi ◽  
Tissue Damage ◽  
Ex Vivo

The ex vivo infection of human placental chorionic villi explants with Trypanosoma cruzi and Toxoplasma gondii is mediated by different toll-like receptors

Placenta ◽  
2016 ◽  
Vol 45 ◽  
pp. 86 ◽  
Author(s):  
Lorena Muñoz ◽  
Christian Castillo ◽  
Ileana Carrillo ◽  
Andrea Salinas ◽  
Ana Liempi ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Trypanosoma Cruzi ◽  
Ex Vivo ◽  
Toll Like Receptors ◽  
Chorionic Villi

Congenital infection of protozoa: Histopathological and histochemical analysis of human chorionic villi explants infected ex vivo with Trypanosoma cruzi and Toxoplasma gondii

Placenta ◽  
2014 ◽  
Vol 35 (9) ◽  
pp. A61-A62
Author(s):  
Ana Liempi ◽  
Daniel Droguett ◽  
Christian Castillo ◽  
Alexandra Sandoval ◽  
Priscilla Figueroa ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Trypanosoma Cruzi ◽  
Ex Vivo ◽  
Congenital Infection ◽  
Histochemical Analysis ◽  
Chorionic Villi

Role the NF-kappa B signal pathways during the ex vivo infection of human placenta with Trypanosoma cruzi and Toxoplasma gondii

Placenta ◽  
2019 ◽  
Vol 83 ◽  
pp. e39
Author(s):  
Ana Liempi ◽  
Christian Castillo ◽  
Lisvaneth Medina ◽  
Catalina Espinoza ◽  
Emilia Corradi ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Trypanosoma Cruzi ◽  
Human Placenta ◽  
Ex Vivo ◽  
Signal Pathways ◽  
Nf Kappa B

Ex vivo infection of canine and ovine placental explants with Trypanosoma cruzi and Toxoplasma gondii: differential activation of NF kappa B signaling pathways

Acta Tropica ◽  
2021 ◽  
Vol 214 ◽  
pp. 105766
Author(s):  
Ana Liempi ◽  
Christian Castillo ◽  
Lisvaneth Medina ◽  
Maura Rojas-Pirela ◽  
Sebastian Araneda ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Trypanosoma Cruzi ◽  
Signaling Pathways ◽  
Ex Vivo ◽  
Nf Kappa B ◽  
Differential Activation

Ex vivo infection of human placental explants with Trypanosoma cruzi and Toxoplasma gondii: Differential activation of NF kappa B signaling pathways

Acta Tropica ◽  
2019 ◽  
Vol 199 ◽  
pp. 105153 ◽  
Author(s):  
Ana Liempi ◽  
Christian Castillo ◽  
Lisvaneth Medina ◽  
Maura Rojas ◽  
Juan Diego Maya ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Trypanosoma Cruzi ◽  
Signaling Pathways ◽  
Ex Vivo ◽  
Nf Kappa B ◽  
Differential Activation

Trypanosoma cruzi Infection in Mice Chronically Infected with Toxoplasma gondii

1977 ◽  
Vol 63 (6) ◽  
pp. 1120 ◽  
Author(s):  
Fausto G. Araujo ◽  
Evaldo Nascimento
Keyword(s):  
Toxoplasma Gondii ◽  
Trypanosoma Cruzi ◽  
Cruzi Infection

Transcriptome study of human placental chorionic villous explants (HPCVE) infected ex vivo with Trypanosoma cruzi

Placenta ◽  
2015 ◽  
Vol 36 (4) ◽  
pp. 494
Author(s):  
Castillo Christian ◽  
Libisch Gabriela ◽  
Liempi Ana ◽  
Carrillo Ileana ◽  
Droguett Daniel ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Ex Vivo

scholarly journals Toxoplasma gondii injected neurons localize to the cortex and striatum and have altered firing

2021 ◽  
Author(s):  
Oscar A. Mendez ◽  
Emiliano Flores Machado ◽  
Jing Lu ◽  
Anita A. Koshy
Keyword(s):  
Toxoplasma Gondii ◽  
Single Neuron ◽  
Latent Infection ◽  
Ex Vivo ◽  
Medium Spiny Neurons ◽  
Patch Clamping ◽  
Spiny Neurons ◽  
The Brain ◽  
Mapping Program

AbstractToxoplasma gondii is an intracellular parasite that causes a long-term latent infection of neurons. Using a custom MATLAB-based mapping program in combination with a mouse model that allows us to permanently mark neurons injected with parasite proteins, we found that Toxoplasma-injected neurons (TINs) are heterogeneously distributed in the brain, primarily localizing to the cortex followed by the striatum. Using immunofluorescence co-localization assays, we determined that cortical TINs are commonly (>50%) excitatory neurons (FoxP2+) and that striatal TINs are often (>65%) medium spiny neurons (MSNs) (FoxP2+). As MSNs have highly characterized electrophysiology, we used ex vivo slices from infected mice to perform single neuron patch-clamping on striatal TINs and neighboring uninfected MSNs (bystander MSNs). These studies demonstrated that TINs have highly abnormal electrophysiology, while the electrophysiology of bystander MSNs was akin to that of MSNs from uninfected mice. Collectively, these data offer new neuroanatomic and electrophysiologic insights into CNS toxoplasmosis.

scholarly journals El Estudio de las Infecciones Congénitas por Toxoplasma Gondii y Trypanosoma Cruzi

1985 ◽  
Vol 56 (3) ◽  
Author(s):  
Erica Thiermann ◽  
Patricia Mufioz C. del V ◽  
Myriam Lorca H ◽  
Antonio Atias M
Keyword(s):  
Toxoplasma Gondii ◽  
Trypanosoma Cruzi
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