Poster 269: Open-label Extension Study on the Long-Term Safety, Impact on Quality of Life and Clinical Utility of OROS® Hydromorphone Extended Release in Patients with Chronic Low Back Pain

PM&R ◽  
2009 ◽  
Vol 1 ◽  
pp. S220-S221
Author(s):  
Mark S. Wallace ◽  
John Thipphawong
Keyword(s):  
Quality Of Life ◽  
Low Back Pain ◽  
Back Pain ◽  
Clinical Utility ◽  
Extended Release ◽  
Low Back ◽  
Open Label ◽  
Open Label Extension

Evaluation of quality of life following treatment with etoricoxib in patients with arthritis or low-back pain: an open label, uncontrolled pilot study in Mexico

2004 ◽  
Vol 20 (5) ◽  
pp. 691-698 ◽  
Author(s):  
Cesar R. Ramos-Remus ◽  
Elke Hunsche ◽  
Panagiotis Mavros ◽  
Julio Querol ◽  
Rafael Suarez ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Low Back Pain ◽  
Back Pain ◽  
Pilot Study ◽  
Low Back ◽  
Open Label

scholarly journals A randomized, open-label study of once-a-day AVINZA® (morphine sulfate extended-release capsules) versus twice-a-day OxyContin® (oxycodone hydrochloride controlled-release tablets) for chronic low back pain: The extension phase of the ACTION trial

2006 ◽  
Vol 2 (6) ◽  
pp. 325 ◽  
Author(s):  
Richard L. Rauck, MD ◽  
Stephen A. Bookbinder, MD ◽  
Timothy R. Bunker, MD ◽  
Christopher D. Alftine, MD ◽  
Richard Ghalie, MD ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Extended Release ◽  
Extension Phase ◽  
Low Back ◽  
Open Label ◽  
Pain Scores ◽  
Evaluation Phase ◽  
Morphine Equivalent

Study design and objective: The ACTION ® trial, an open-label, randomized, multicenter, two-part study, compared the efficacy and safety of two sustained-release opioids (SROs), AVINZA (A-MQD), morphine sulfate extended-release capsules given once a day, and OxyContin® (O-ER), oxycodone modified-release tablets given twice a day, in subjects with chronic, moderate to severe low back pain. The first part of the study, the evaluation phase, was followed by an optional four-month extension phase aimed at evaluating the long-term stability of pain control, SRO dose, and quality of sleep.Results: Three hundred and ninety-two subjects were enrolled in the study; 220 completed the evaluation phase, and 174 entered the extension phase. During the latter phase, subjects in the A-MQD group (n = 79) continued to report lower pain scores, better quality of sleep, lower daily morphine-equivalent doses (means of 86 mg versus 119 mg), and a comparable usage of ibuprofen compared to subjects in the O-ER group (n = 95). The incidence and severity of elicited opioid side effects were similar between the two groups.Conclusions: Both study drugs resulted in significant pain relief and improved sleep in SRO-naive patients with chronic low back pain, and this outcome was attained with a stable daily SRO dose. In patients who completed opioid dose titration, AVINZA performed significantly better than OxyContin in reducing pain scores and improving sleep—with a lower morphine-equivalent daily dose—during both the evaluation and extension phases.

scholarly journals Influence of Mckenzie protocol and two modes of endurance exercises on health-related quality of life of patients with long-term mechanical low-back pain

2014 ◽  
Vol 17 ◽  
Author(s):  
Chidozie Emmanuel Mbada ◽  
Olusola Ayanniyi ◽  
Samuel Olusegun Ogunlade ◽  
Elkanah Ayodele Orimolade ◽  
Ajibola Babatunde Oladiran ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Low Back Pain ◽  
Back Pain ◽  
Low Back ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Psychological Interventions in Chronic Low Back Pain: A Systematic Review

2021 ◽  
Vol 7 (2) ◽  
pp. 67-74
Author(s):  
Sajjad Saadat ◽  
◽  
Mozaffar Hosseininezhad ◽  
Seyed Sepehr Khatami ◽  
Reza Ghasemi Jobaneh ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Clinical Trials ◽  
Low Back Pain ◽  
Back Pain ◽  
Psychological Interventions ◽  
Low Back

Background and Aim: Chronic low Back Pain (CLBP) is one of the most common musculoskeletal disorders with possible psychological consequences for the patients. This study aimed to review all evidence on the effectiveness of psychological interventions in improving the mental status of people with CLBP and providing recommendations for future therapeutic interventions. Methods and Materials/Patients: This systematic review was conducted on the articles published from January 2010 to December 2020. The keywords included “psychology”, “intervention”, “low back pain”, “chronic disease”, “quality of life”, “empowerment”, “psychotherapy”, “psychological interventions”, “clinical trials”, and “randomized clinical trials” in the indexing databases of Magiran, PubMed, Scopus, and Google Scholar. Of the total 1740 articles found, 14 articles were selected for review. Results: The results showed that Cognitive-Behavioral Therapy (CBT) and its combination therapies with mindfulness techniques played an influential role in improving psychological status and quality of life, and reducing pain perception in CLBP patients. The lack of RCT (randomized controlled trial) research and follow-up to assess long-term outcomes are the main limitations of the studies conducted in Iran. Conclusion: It is recommended that psychological interventions be considered alongside medical therapies to improve CLBP patients’ adjustment to chronic condition and their quality of life. Researchers and therapists should consider treatment programs based on RCT plans and long-term follow-up.

Health-Related Quality of Life and Somatization in Patients With Long-Term Low Back Pain

Spine ◽  
2001 ◽  
Vol 26 (20) ◽  
pp. 2271-2277 ◽  
Author(s):  
R. Nickel ◽  
U. T. Egle ◽  
P. Eysel ◽  
J-D. Rompe ◽  
J. Zöllner ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Low Back Pain ◽  
Back Pain ◽  
Low Back ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related
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