Pilot Study
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2021 ◽  
Vol 161 (1) ◽  
pp. e22
Author(s):  
Ahmad Alkaddour ◽  
Amit Hudgi ◽  
Anabel Liyen Cartelle ◽  
Amr Ahmed ◽  
Carlos Palacio ◽  
...  

Author(s):  
Debra A. Dickson ◽  
Laura Gantt ◽  
Melvin Swanson

BACKGROUND Restraint and seclusion continue to be used with patients demonstrating aggressive and violent behaviors while in the emergency department and as inpatients in behavioral health (BH) units. The use of sensory interventions such as the weighted blanket (WB) is garnering interest as alternatives to aid in managing anxiety, anger, and aggressive behaviors. Reports of the effectiveness of the WB have primarily been anecdotal, and results of research with children have been mixed. Only one study has been conducted with the WB with adults on an inpatient psychiatric unit. OBJECTIVES The aim of this pilot study was to assess the effectiveness of the WB by determining whether it decreases anxiety and/or anger in adult emergency department patients with preexisting psychiatric diagnoses. METHODS The study used a quasi-experimental, nonequivalent control group design with pre- and posttests for anxiety and anger. The intervention was a 15-pound WB. Participants ( N = 15) were in one of three groups, which included no weighted blanket (NWB), WB for 15 minutes, or WB for 30 minutes. RESULTS All three groups showed a decrease in anxiety and anger scores. However, participants in the WB groups had a greater decrease in anxiety and anger posttest scores. CONCLUSIONS The small sample size in this study did not allow for the determination of any differences between groups on anxiety or anger scores that could be viewed as a significant finding.


2021 ◽  
Vol 12 ◽  
Author(s):  
Silke Bachmann ◽  
Michaela Beck ◽  
Dai-Hua Tsai ◽  
Friederike Haupt

Neurological soft signs (NSS) represent minor neurological features and have been widely studied in psychiatric disease. The assessment is easily performed. Quantity and quality may provide useful information concerning the disease course. Mostly, NSS scores differ significantly between patients and controls. However, literature does not give reference values. In this pilot study, we recruited 120 healthy women and men to build a cross-sectional, census-based sample of healthy individuals, aged 20 to >70 years, subdivided in 10-year blocks for a close approach to the human lifeline. Testing for NSS and neurocognitive functioning was performed following the exclusion of mental and severe physical illness. NSS scores increased significantly between ages 50+ and 60+, which was primarily accountable to motor signs. Gender and cognitive functioning were not related to changes of scores. Although the number of individuals is small, study results may lay a foundation for further validation of NSS in healthy individuals.


MAPAN ◽  
2021 ◽  
Author(s):  
Santwana Pati ◽  
Goutam Mandal ◽  
Nidhi Singh ◽  
Manoj Kumar ◽  
D. C. Sharma

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3161
Author(s):  
Nam H. K. Nguyen ◽  
Huiyun Wu ◽  
Haiyan Tan ◽  
Junmin Peng ◽  
Jeffrey E. Rubnitz ◽  
...  

Acute Myeloid Leukemia (AML) is a heterogeneous disease with several recurrent cytogenetic abnormalities. Despite genomics and transcriptomics profiling efforts to understand AML’s heterogeneity, studies focused on the proteomic profiles associated with pediatric AML cytogenetic features remain limited. Furthermore, the majority of biological functions within cells are operated by proteins (i.e., enzymes) and most drugs target the proteome rather than the genome or transcriptome, thus, highlighting the significance of studying proteomics. Here, we present our results from a pilot study investigating global proteomic profiles of leukemic cells obtained at diagnosis from 16 pediatric AML patients using a robust TMT-LC/LC-MS/MS platform. The proteome profiles were compared among patients with or without core binding factor (CBF) translocation indicated by a t(8;21) or inv(16) cytogenetic abnormality, minimal residual disease status at the end of the first cycle of chemotherapy (MRD1), and in vitro chemosensitivity of leukemic cells to cytarabine (Ara-C LC50). Our results established proteomic differences between CBF and non-CBF AML subtypes, providing insights to AML subtypes physiology, and identified potential druggable proteome targets such as THY1 (CD90), NEBL, CTSF, COL2A1, CAT, MGLL (MAGL), MACROH2A2, CLIP2 (isoform 1 and 2), ANPEP (CD13), MMP14, and AK5.


Author(s):  
Adam W. Hanley ◽  
Vincent Dehili ◽  
Deidre Krzanowski ◽  
Daniela Barou ◽  
Natalie Lecy ◽  
...  

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0253819
Author(s):  
Stefan Altmann ◽  
Rainer Neumann ◽  
Sascha Härtel ◽  
Gunther Kurz ◽  
Thorsten Stein ◽  
...  

The purpose of this study was to examine the relationships of physical and perceptual-cognitive factors with agility performance in amateur soccer players. Fifteen male amateur soccer players (age, 24.5 ± 1.9 years) completed a linear-sprint test with splits at 5 m, 10 m, and 30 m, a change-of-direction test of 12 m with 2 pre-planned directional changes of 45° at 2 m and 7 m, and a soccer-specific agility test with same movement pattern as the change-of-direction test but with the inclusion of a human stimulus performing passing movements. Additionally, the perceptual-cognitive deficit (agility performance minus change-of-direction performance) was calculated. In relation to agility performance, linear-sprint performance showed large relationships, which were higher with increasing sprint distance (5 m, r = 0.57; 10 m, r = 0.59; 30 m, r = 0.69), change-of-direction performance a very large relationship (r = 0.77), and the perceptual-cognitive deficit a large relationship (r = 0.55). The findings of this study highlight the relatively high contribution of both physical (i.e., linear-sprint and change-of-direction performance) and perceptual-cognitive factors (i.e., perceptual-cognitive deficit) in relation to soccer-specific agility performance at an amateur level. Consequently, such elements might be recommended to be included in training programs aimed at improving agility performance at this playing level. Moreover, the here introduced perceptual-cognitive deficit allows for a convenient and likewise thorough analysis of agility performance. Future studies should investigate the effects of both physically and perceptual-cognitive oriented training interventions on agility performance, which is considered a key element for success in soccer.


2021 ◽  
Vol 11 (7) ◽  
pp. 596
Author(s):  
Heather Way ◽  
Grant Williams ◽  
Sharon Hausman-Cohen ◽  
Jordan Reeder

Considerable evidence is emerging that Autism Spectrum Disorder (ASD) is most often triggered by a range of different genetic variants that interact with environmental factors such as exposures to toxicants and changes to the food supply. Up to 80% of genetic variations that contribute to ASD found to date are neither extremely rare nor classified as pathogenic. Rather, they are less common single nucleotide polymorphisms (SNPs), found in 1–15% or more of the population, that by themselves are not disease-causing. These genomic variants contribute to ASD by interacting with each other, along with nutritional and environmental factors. Examples of pathways affected or triggered include those related to brain inflammation, mitochondrial dysfunction, neuronal connectivity, synapse formation, impaired detoxification, methylation, and neurotransmitter-related effects. This article presents information on four case study patients that are part of a larger ongoing pilot study. A genomic clinical decision support (CDS) tool that specifically focuses on variants and pathways that have been associated with neurodevelopmental disorders was used in this pilot study to help develop a targeted, personalized prevention and intervention strategy for each child. In addition to an individual’s genetic makeup, each patient’s personal history, diet, and environmental factors were considered. The CDS tool also looked at genomic SNPs associated with secondary comorbid ASD conditions including attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety, and pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections/pediatric acute-onset neuropsychiatric syndrome (PANDAS/PANS). The interpreted genomics tool helped the treating clinician identify and develop personalized, genomically targeted treatment plans. Utilization of this treatment approach was associated with significant improvements in socialization and verbal skills, academic milestones and intelligence quotient (IQ), and overall increased ability to function in these children, as measured by autism treatment evaluation checklist (ATEC) scores and parent interviews.


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