Unusual cause of chest pain, Bornholm disease, a forgotten entity; case report and review of literature

Introduction Intrathoracic extravasation of anthracyclines is a dangerous and very rare complication of chemotherapy administration. While management of extravasation into soft tissues has been established, the data on treatment of mediastinal and intrapleural anthracycline extravasation is limited. Case Report We present a case of a 52-year-old woman with intrapleural doxorubicin extravasation who presented to the hospital 24-hrs after chemotherapy infusion with chest pain and shortness of breath. Management & Outcome The patient underwent urgent surgical intervention and received IV dexrazoxane 36-hrs after the event. Her pain improved, but she continued to have chest soreness and pleural effusion at the site of extravasation even 3 months later. Discussion We conducted review of literature using Medline/PubMed and Google Scholar databases and identified 7 cases of intrapleural and mediastinal anthracycline extravasation. No data is currently available regarding the outcome of delayed management of intrapleural anthracycline extravasation with dexrazoxane. Prevention and confirmation of adequate port catheter placement is the most important step to avoid such cases. Catheter misplacement should be suspected in any patient presenting with post procedural chest pain and should trigger a thorough evaluation prior to any chemotherapy administration.

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Proximal nerve root capillary hemangioma presenting as a lung mass with bandlike chest pain: case report and review of literature

Surgical Neurology ◽

10.1016/j.surneu.2005.07.070 ◽

2006 ◽

Vol 65 (6) ◽

pp. 584-589 ◽

Cited By ~ 19

Author(s):

Jennifer S. Kang ◽

Kevin O. Lillehei ◽

Bette K. Kleinschmidt-DeMasters

Keyword(s):

Case Report ◽

Chest Pain ◽

Nerve Root ◽

Capillary Hemangioma ◽

Review Of Literature ◽

Lung Mass

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Chest pain caused by multiple exostoses of the ribs: A case report and a review of literature

World Journal of Orthopedics ◽

10.5312/wjo.v8.i5.436 ◽

2017 ◽

Vol 8 (5) ◽

pp. 436 ◽

Cited By ~ 1

Author(s):

Daniele Mazza ◽

Mattia Fabbri ◽

Cosma Calderaro ◽

Carlo Iorio ◽

Luca Labianca ◽

...

Keyword(s):

Case Report ◽

Chest Pain ◽

Review Of Literature ◽

Multiple Exostoses

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Discordant troponin I value in a young woman: a case report with review of literature

Turkish Journal of Biochemistry ◽

10.1515/tjb-2018-0313 ◽

2019 ◽

Vol 44 (2) ◽

pp. 224-228

Author(s):

Didem Barlak Keti ◽

Sabahattin Muhtaroğlu ◽

Leyla Öz ◽

Nahide Ekici Günay

Keyword(s):

Emergency Department ◽

Case Report ◽

Chest Pain ◽

Young Woman ◽

Troponin I ◽

Review Of Literature ◽

Clinical Laboratories ◽

Single Method ◽

Assay Interference ◽

Serial Dilutions

Abstract Objective We reported a young woman who had false high troponin value due to antibody interference. Our aim is to look at the approaches to be taken into consideration in determining troponin (Tn) assay interference. Patients and methods A 36-year-old woman presented to the emergency department with chest pain. At presentation, TnI value was found 2.26 ng/mL (99th percentile <0.01 ng/mL). Troponin measurements were repeated with alternative platforms. Serum sample of the patient was treated with heterophile antibody blocking tube (HBT). In addition, polyethylene glycol (PEG) precipitation and serial dilutions were applied to serum. Results All of the Tn results in alternative platforms were found under cut off value and serial dilutions of patient serum did not show linearity. After PEG precipitation, TnI value was decreased from 2.34 ng/mL to 0.01 ng/mL (recovery: 0.85%), suggesting antibody interference. Incubation of the patient sample with HBT showed 93.1% of recovery. Conclusion To investigate the presence of interference, use of multiple methods that can be applied in the clinical laboratories is more reliable than a single method.

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