scholarly journals Reductions in blood concentrations of persistent organic pollutants in the general population of Barcelona from 2006 to 2016

2021 ◽  
pp. 146013
Author(s):  
Miquel Porta ◽  
José Pumarega ◽  
Luis A. Henríquez-Hernández ◽  
Magda Gasull ◽  
Xavier Bartoll ◽  
...  
Keyword(s):  
General Population ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Blood Concentrations

Blood Concentrations of Persistent Organic Pollutants and Prediabetes and Diabetes in the General Population of Catalonia

2012 ◽  
Vol 46 (14) ◽  
pp. 7799-7810 ◽  
Author(s):  
Magda Gasull ◽  
José Pumarega ◽  
María Téllez-Plaza ◽  
Conxa Castell ◽  
Ricard Tresserras ◽  
...  
Keyword(s):  
General Population ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Blood Concentrations

scholarly journals A Human Relevant Defined Mixture of Persistent Organic Pollutants (POPs) Affects In Vitro Secretion of Glucagon-Like Peptide 1 (GLP-1), but Does Not Affect Translocation of Its Receptor

2019 ◽  
Vol 172 (2) ◽  
pp. 359-367 ◽  
Author(s):  
Maeve Shannon ◽  
Yuling Xie ◽  
Steven Verhaegen ◽  
Jodie Wilson ◽  
Hanne F Berntsen ◽  
...  
Keyword(s):  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Complex Mixture ◽  
Blood Levels ◽  
Environmental Toxicants ◽  
Blood Concentrations ◽  
Total Mixture ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Abstract Environmental exposure to persistent organic pollutants (POPs) has been suggested as a contributing factor for the increased rate of type 2 diabetes and obesity. A complex mixture of 29 POPs (Total mixture), based on human blood concentrations, was used to expose a glucagon-like peptide 1 (GLP-1) secreting enteroendocrine cell line (pGIP/neo: STC-1) in vitro for 3 and 24 h. Significant increases of GLP-1 occurred when cells were exposed to the Total mixture at ×500 blood levels. Six sub-mixtures representing chlorinated (Cl), brominated (Br), and perfluorinated chemicals (PFAA), and their combinations (Cl + Br, Cl + PFAA, Br + PFAA) were also tested at ×500. Secretion levels seen for these remained lower than the Total mixture, and the Br mixture had no effect. After 24 h, increased secretion was seen with all mixtures at ×1 blood levels. Cytotoxicity was present for ×100 and ×500 blood levels. When tested in a GLP-1 receptor translocation assay (U2OS-GLP1R-EGFP), neither agonistic nor antagonist effects on receptor internalization were seen for any of the mixtures. We conclude individual classes of POPs, alone or in combination, can affect GLP-1 secretion and may contribute as a molecular mechanism linking environmental toxicants and diabetes.

scholarly journals Blood Concentrations of Persistent Organic Pollutants and Unhealthy Metabolic Phenotypes in Normal-Weight, Overweight, and Obese Individuals

2017 ◽  
Vol 187 (3) ◽  
pp. 494-506 ◽  
Author(s):  
Magda Gasull ◽  
Conxa Castell ◽  
Natàlia Pallarès ◽  
Carme Miret ◽  
José Pumarega ◽  
...  
Keyword(s):  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Normal Weight ◽  
Blood Concentrations ◽  
Metabolic Phenotypes

Monitoring concentrations of persistent organic pollutants in the general population: The international experience

2008 ◽  
Vol 34 (4) ◽  
pp. 546-561 ◽  
Author(s):  
Miquel Porta ◽  
Elisa Puigdomènech ◽  
Ferran Ballester ◽  
Javier Selva ◽  
Núria Ribas-Fitó ◽  
...  
Keyword(s):  
General Population ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
International Experience

scholarly journals Effects of Defined Mixtures of Persistent Organic Pollutants (POPs) on Pre-lethal Cytotoxicity in the Human A-498 Kidney Cell Line In Vitro

2021 ◽  
Author(s):  
Mazia Amber ◽  
Yuling Xie ◽  
Hanne Friis Berntsen ◽  
Karin Elizabeth Zimmer ◽  
Erik Ropstad ◽  
...  
Keyword(s):  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Cell Number ◽  
Alternative Mechanism ◽  
Blood Concentrations ◽  
Mitochondrial Mass ◽  
Total Mixture ◽  
High Content Analysis ◽  
Level 1

AbstractA total mixture of 29 persistent organic pollutants (POPs) modelled from Scandinavian blood concentrations was used to expose human A-498 kidney cells for 24 h over a concentration range spanning below to above blood level (1/10x, 1x, 50x, 100x, 500x). Its constituent submixtures (PFAA, Br, Cl) and co-mixtures (PFAA + Br, PFAA + Cl, Br + Cl) were also tested. Valinomycin (12 µM) was used as a cytotoxic comparative compound. Cell number (CN), nuclear area (NA), nuclear intensity (NI), mitochondrial membrane potential (MMP), and mitochondrial mass (MM) were assessed using high content analysis (HCA). Only the co-mixtures (PFAA + Cl, PFAA + Br) at 50x and 50x, 500x decreased CN, respectively. NI was increased by the total mixture at 500x and Cl mixture at all concentrations tested. MMP was increased by the total mixture at 100x and 500x, PFAA at 1x, Br + Cl and PFAA + Cl at 100x and 500x, respectively. MM was decreased by the total mixture at 500x. In contrast, valinomycin decreased CN and surviving cells showed a decrease in MMP and an increase in MM. In conclusion, POP exposure altered mitochondrial metabolism and induced cell death via an alternative mechanism to valinomycin. Only specific combinations of individual chemical classes, but not the total mixture, affected cell number.

Distribution of blood concentrations of persistent organic pollutants in a representative sample of the population of Catalonia

2010 ◽  
Vol 36 (7) ◽  
pp. 655-664 ◽  
Author(s):  
Miquel Porta ◽  
Magda Gasull ◽  
Elisa Puigdomènech ◽  
Mercè Garí ◽  
Magda Bosch de Basea ◽  
...  
Keyword(s):  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Representative Sample ◽  
Blood Concentrations
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