scholarly journals Generation of a human iPS cell line (CABi003-A) from a patient with age-related macular degeneration carrying the CFH Y402H polymorphism

2019 ◽  
Vol 38 ◽  
pp. 101473 ◽  
Author(s):  
Ana B. Garcia-Delgado ◽  
Sofia M. Calado ◽  
Lourdes M. Valdes-Sanchez ◽  
Adoracion Montero-Sanchez ◽  
Beatriz Ponte-Zuñiga ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Cell Line ◽  
Age Related Macular Degeneration ◽  
Ips Cell ◽  
Age Related ◽  
Y402h Polymorphism

Evaluation of CFH Y402H polymorphism and CFHR3/CFHR1 deletion in age-related macular degeneration patients from Brazil

2016 ◽  
Vol 37 (4) ◽  
pp. 459-461 ◽  
Author(s):  
Daniela Prescila Dezidério Sacconi ◽  
José Paulo Cabral de Vasconcellos ◽  
Fábio Endo Hirata ◽  
Flávio MacCord Medina ◽  
Priscila Hae Hyun Rim ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Y402h Polymorphism

Complement factor H Y402H polymorphism and characteristics of exudative age-related macular degeneration lesions

2008 ◽  
Vol 86 (4) ◽  
pp. 390-394 ◽  
Author(s):  
Sanna Seitsonen ◽  
Irma Järvelä ◽  
Seppo Meri ◽  
Petri Tommila ◽  
Päivi Ranta ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Factor H ◽  
Age Related Macular Degeneration ◽  
Complement Factor H ◽  
Complement Factor ◽  
Age Related ◽  
Y402h Polymorphism

scholarly journals Association of complement factor H Y402H polymorphism and age-related macular degeneration in Brazilian patients

2010 ◽  
Vol 88 (5) ◽  
pp. e165-e169 ◽  
Author(s):  
Anderson G. Teixeira ◽  
Aldacilene S. Silva ◽  
Fabio L.H. Lin ◽  
Roberta Velletri ◽  
Lorena Bavia ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Factor H ◽  
Age Related Macular Degeneration ◽  
Complement Factor H ◽  
Complement Factor ◽  
Age Related ◽  
Y402h Polymorphism

Y402H Polymorphism in Complement Factor H and Age-Related Macular Degeneration in the Tunisian Population

2013 ◽  
Vol 49 (4) ◽  
pp. 177-184 ◽  
Author(s):  
I. Habibi ◽  
I. Sfar ◽  
F. Kort ◽  
H. Aounallah-Skhiri ◽  
A. Chebil ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Factor H ◽  
Age Related Macular Degeneration ◽  
Complement Factor H ◽  
Tunisian Population ◽  
Complement Factor ◽  
Age Related ◽  
Y402h Polymorphism

scholarly journals CFH Y402H polymorphism and response to intravitreal Ranibizumab in brazilian patients with neovascular age-related macular degeneration

2014 ◽  
Vol 41 (6) ◽  
pp. 386-392 ◽  
Author(s):  
Carlos Eduardo Veloso ◽  
Luciana Negrão Frota de Almeida ◽  
Márcio Bittar Nehemy
Keyword(s):  
Macular Degeneration ◽  
Retinal Thickness ◽  
Age Related Macular Degeneration ◽  
Paired Comparisons ◽  
Nucleotide Polymorphism ◽  
Intravitreal Ranibizumab ◽  
Single Nucleotide ◽  
Age Related ◽  
Y402h Polymorphism

Objective: To investigate the association between CFH gene polymorphism and response to ranibizumab in Brazilian patients with neovascular age-related macular degeneration (AMD).Methods: 95 patients were genotyped for the CFH rs1061170 (Y402H) single nucleotide polymorphism. Patients with neovascular AMD initially received intravitreal ranibizumab injections for three months and were retreated as needed. Visual acuity (VA) and central retinal thickness (CRT) were measured before treatment and at 1, 3, 6, and 12 months post-treatment.Results: For patients with the TT and TC genotypes, paired comparisons of VA showed a statistically significant improvement when the data obtained at all visits were compared with baseline. Patients homozygous for the risk genotype (CC) did not show a statistically significant improvement when VA obtained at visits 1, 3, 6 and 12 were compared with baseline. For all genotypes, paired comparisons of CRT showed a statistically significant improvement when the data obtained at visits 1, 3, 6 and 12 were compared with baseline.Conclusion: Patients with the CC genotype showed poorer long-term functional response to intravitreal ranibizumab.

Sign in / Sign up

Export Citation Format

Share Document