Studies on the ɑ-lithiation-in situ intramolecular nucleophilic addition reactions of 2-acyl-N-sulfonylpyrroles

2021 ◽  
pp. 152907
Author(s):  
Cui Zhao ◽  
Chuanjun Song
Keyword(s):  
Nucleophilic Addition ◽  
Addition Reactions

Regioselective Functionalization of N-Fused Heteroaromatics via FeCl3-Catalyzed Nucleophilic Addition to Activated N-Heterocycles

Synthesis ◽  
2020 ◽  
Author(s):  
Ikyon Kim ◽  
Sung June Kim ◽  
Sunhee Lee
Keyword(s):  
Aromatic Compounds ◽  
Nucleophilic Addition ◽  
Chemical Space ◽  
Wide Range ◽  
Regioselective Functionalization

AbstractBroadening of nitrogen-fused heteroaromatic chemical space such as indolizine and pyrrolo[1,2-a]pyrazine was achieved via FeCl­3-catalyzed nucleophilic addition of these N-fused aromatic compounds to a wide range of azolinium systems generated in situ, leading to novel N-fused heteroaromatic scaffolds with dearomatized N-heterocyclic substituents regioselectively. Nucleophilic addition of indolizines and pyrrolo[1,2-a]pyrazines mainly occurred at the C1 position of the isoquinoliniums and at the C4 site of the quinoliniums.

scholarly journals Nucleophilic Addition Reactions of Nitriles to Nitrones under Mild Silylation Conditions

Synlett ◽  
2014 ◽  
Vol 25 (13) ◽  
pp. 1863-1868 ◽  
Author(s):  
Fumihiko Yoshimura ◽  
Keiji Tanino ◽  
Taiki Abe
Keyword(s):  
Nucleophilic Addition ◽  
Addition Reactions

Amide-Directed Reactions of Small Carbocycles

2021 ◽  
Vol 25 ◽  
Author(s):  
Pavel M. Yamanushkin ◽  
Marina Rubina ◽  
Michael Rubin
Keyword(s):  
Transition Metal ◽  
Transition Metals ◽  
Nucleophilic Addition ◽  
Addition Reactions ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

: The topic of this review is the amide-directed functionalization of strained carbocycles — specifically, unsaturated or saturated three- and four-membered rings. The following approaches are discussed: a) directed carbometallation and hydrometallation of cyclopropenes catalyzed by transition metals; b) directed metal-templated nucleophilic addition reactions; c) directed C-H functionalization, including transition metal-catalyzed C-H-activation reactions; and d) directed radical additions.

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