The Effects of Phenylephrine and Diltiazem on Cardiovascular Function in Anesthetized and Conscious Beagle Dogs: Considerations for Estimating Pulmonary Artery Pressure from Right Ventricular Pressure

2017 ◽  
Vol 88 ◽  
pp. 229
Author(s):  
Brian Roche ◽  
R. Brandon Borders ◽  
Jason Kieper ◽  
Kasey Landis ◽  
Kate Vosss
Keyword(s):  
Pulmonary Artery ◽  
Right Ventricular ◽  
Pulmonary Artery Pressure ◽  
Cardiovascular Function ◽  
Ventricular Pressure ◽  
Beagle Dogs ◽  
Artery Pressure

Serotonin transporter protein in pulmonary hypertensive rats treated with atorvastatin

2007 ◽  
Vol 293 (3) ◽  
pp. L630-L638 ◽  
Author(s):  
Sven Laudi ◽  
Saskia Trump ◽  
Volker Schmitz ◽  
James West ◽  
Ivan F. McMurtry ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Right Ventricular ◽  
Pulmonary Artery Pressure ◽  
Serotonin Transporter ◽  
Transthoracic Echocardiography ◽  
Ventricular Pressure ◽  
Atorvastatin Treatment ◽  
Artery Pressure ◽  
Transporter Protein ◽  
Serotonin Transporter Protein

HMG-CoA-reductase inhibitors (statins) influence lipid metabolism and have pleiotropic effects. Several statins reduce various forms of pulmonary hypertension (PH) in animal models. The relationship between atorvastatin and expression of serotonin transporter protein (5-HTT) remains unknown. This study focused on the effects of atorvastatin on the course of monocrotaline (MCT)-induced PH and its relation to 5-HTT expression. Male Sprague-Dawley rats were challenged with MCT with or without subsequent daily oral treatment with 0.1, 1, and 10 mg/kg of atorvastatin for 28 days. Over the 4-wk course, the progression of PH was followed by transthoracic echocardiography [pulmonary artery pressure was assessed by pulmonary artery flow acceleration time (PAAT), an estimate reciprocal to pulmonary artery pressure], and, at the end of the 4-wk course, invasive right ventricular pressure, right ventricular weight, quantitative morphology, and 5-HTT expression were measured. MCT caused significant PH as early as 7 days after injection. Atorvastatin treatment increased PAAT and reduced right ventricular pressure, right ventricular hypertrophy, and vascular remodeling over the 4-wk course. MCT challenge was associated with increased pulmonary vascular 5-HTT expression, and atorvastatin treatment reduced the 5-HTT expression. MCT-induced PH over the course of 4 wk can be easily followed by transthoracic echocardiography, and atorvastatin is effective in reducing the PH. Atorvastatin's effects are associated with a decrease of 5-HTT expression.

Right Ventricular Oscillatory Power Is a Constant Fraction of Total Power Irrespective of Pulmonary Artery Pressure

2010 ◽  
Vol 182 (10) ◽  
pp. 1315-1320 ◽  
Author(s):  
Nabil Saouti ◽  
Nico Westerhof ◽  
Frank Helderman ◽  
J. Tim Marcus ◽  
Anco Boonstra ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Right Ventricular ◽  
Pulmonary Artery Pressure ◽  
Total Power ◽  
Artery Pressure ◽  
Oscillatory Power
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